Ginsenoside Rb decreases the TSCC tumor cell viability and promotes apoptosis to decrease the tumor size by interacting with E-cadherin

Abstract

Ginsenoside Rd is a small molecule compound found in ginseng. In traditional Chinese medicine theory, it has anti-inflammatory, anti-edema, blood-activating, and debriding effects. In recent clinical trials, Rd has shown an effect of promoting cancer cell apoptosis, especially for oral cancer, with good curative effects. The specific mechanism of Rd treating cancer is not clear. Another recent study on the e-cadherin protein in cancer cells has given us a new research direction. ECAD is a major calcium-dependent adhesion molecule that is mainly found in cell adhesion in the cell and is usually considered an anti-cancer factor. However, recent research has shown that ECAD is crucial for maintaining cancer cell viability, and it can reduce the content of intracellular ROS by inhibiting TGF-β, P53, and other cellular pathways, thereby reducing the probability of cell death due to oxidative stress. In a series of experiments, a large reduction of ECAD resulted in increased cell apoptosis. This phenomenon is very similar to the effect of Rd on cancer cells. Therefore, this paper aims to study whether the mechanism of Rd treating cancer is related to E-cad.