Curcumin facilitates the treatment of Alzheimer’s disease via augmenting the function of antioxidant enzymes
DOI:
https://doi.org/10.61173/napwqb81Keywords:
-Alzheimer’s disease, curcumin, antioxidant enzymesAbstract
In China, Alzheimer’s disease (AD) affects nearly 10 million people, or about one percent of the population, and how to treat AD has always been the focus of attention. This investigation examined the efficacy of curcumin in the treatment of AD by enhancing the activity of antioxidant enzymes. The findings will elucidate the involvement of the proposed therapeutic mechanisms, specifically the reduction in reactive oxygen species (ROS) and the augmentation of superoxide dismutase (SOD) activity. Unveiling the potential mechanism of action could yield novel insights into the application of curcumin for AD treatment, thereby aiding researchers in the advancement and utilization of curcumin.
References
[1] Elmaleh, D. R., Downey, M. A., Kundakovic, L., Wilkinson, J. E., Neeman, Z., & Segal, E. (2021). New Approaches to Profile the Microbiome for Treatment of Neurodegenerative Disease. Journal of Alzheimer’s disease : JAD, 82(4), 1373–1401.
[2] GBD 2021 Nervous System Disorders Collaborators (2024). Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet. Neurology, 23(4), 344–381.
[3] Scheltens, P., De Strooper, B., Kivipelto, M., Holstege, H., Chételat, G., Teunissen, C. E., Cummings, J., & van der Flier, W. M. (2021). Alzheimer’s disease. Lancet (London, England), 397(10284), 1577–1590.
[4] Weller, J., & Budson, A. (2018). Current understanding of Alzheimer’s disease diagnosis and treatment. F1000Research, 7, F1000 Faculty Rev-1161.
[5] Menon, V.P., Sudheer, A.R., 2007. Antioxidant and antiinflammatory properties of curcumin. Adv. Exp. Med. Biol. 595, 105–125
[6] Farzaei, M.H., Bahramsoltani, R., Rahimi, R., 2016. Phytochemicals as adjunctive with conventional anticancer therapies. Curr. Pharm. Des. 22, 4201–4218.
[7] Kuttan, R.; Bhanumathy, P.; Nirmala, K.; George, M. Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett. 1985, 29, 197–202.
[8] Maheshwari, R. K., Singh, A. K., Gaddipati, J., & Srimal, R. C. (2006). Multiple biological activities of curcumin: a short review. Life sciences, 78(18), 2081–2087.
[9] Bahramsoltani, R., Rahimi, R., & Farzaei, M. H. (2017). Pharmacokinetic interactions of curcuminoids with conventional drugs: A review. Journal of ethnopharmacology, 209, 1–12.
[10] Kovacs T. (2009). Az alzheimer-kór terápiája [Therapy of Alzheimer disease]. Neuropsychopharmacologia Hungarica: a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 11(1), 27–33.
[11] REN XL, XU LL, LV PY, et al. SH-SY5Y cells’ neural differentiation and neurodegenerative diseases[J]. Journal of International Neurology and Neurosurgery,2022,49(3):88-92
[12] Liu, F. F., Zhang, Z., Chen, W., Gu, H. Y., & Yan, Q. J. (2018). Regulatory mechanism of microRNA-377 on CDH13 expression in the cell model of Alzheimer’s disease. European review for medical and pharmacological sciences, 22(9), 2801– 2808.
[13] Lin, X., Bai, D., Wei, Z., Zhang, Y., Huang, Y., Deng, H., & Huang, X. (2019). Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway. PloS one, 14(5), e0216711.
[14] Im, K., Mareninov, S., Diaz, M. F. P., & Yong, W. H. (2019). An Introduction to Performing Immunofluorescence Staining. Methods in molecular biology (Clifton, N.J.), 1897, 299–311.
[15] Motterlini R.; Foresti R.; Bassi R.; Green C. J., Curcumin, an antioxidant and anti-inflammatory agent,induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med2000, 28 (8), 1303–12. Dean&Francis ISSN 2959-409X
[16] Balogun E.; Hoque M.; Gong P.; Killeen E.; Green C. J.; Foresti R.; Alam J.; Motterlini R., Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidantresponsive element. Biochem J 2003, 371 (Pt 3), 887–95.
[17] Reddy, P. H., Manczak, M., Yin, X., Grady, M. C., Mitchell, A., Tonk, S., Kuruva, C. S., Bhatti, J. S., Kandimalla, R., Vijayan, M., Kumar, S., Wang, R., Pradeepkiran, J. A., Ogunmokun, G., Thamarai, K., Quesada, K., Boles, A., & Reddy, A. P. (2018). Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease. Journal of Alzheimer’s disease : JAD, 61(3), 843–866.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 by the authors.
This work is licensed under a Creative Commons Attribution 4.0 International License.
