The Cardioprotective Effects of Vaccinations: An Integrative Analysis
DOI:
https://doi.org/10.61173/9xkeba18Keywords:
cardiovascular disease, vaccinations, influ-enza, pneumonia, tetanus, COVID-19, logistic regression, random forest, public healthAbstract
This study examines the relationship between vaccinations (influenza, pneumonia, tetanus, and COVID-19) and heart disease prevalence using data from the Behavioral Risk Factor Surveillance System (BRFSS). Using logistic regression and Random Forest Classification (RFC) models, the study identified key predictors of cardiovascular disease (CVD). The RFC model demonstrated high accuracy (93.89%) and suggested that vaccinations may reduce CVD risk, though pre-existing health conditions could influence results. The study concludes that vaccinations may be valuable in reducing CVD risk and calls for further research to confirm these findings and understand the mechanisms involved.
References
[1] M. Lindstrom, N. DeCleene, H. Dorsey, V. Fuster, C. O. Johnson, K. E. LeGrand, et al., “Global Burden of Cardiovascular Diseases and Risks Collaboration 1990–2021,” J. Am. Coll. Cardiol., vol. 80, pp. 2372-2425, 2022. DOI: 10.1016/ j.jacc.2022.11.001.
[2] J. A. Udell, et al., “Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a metaanalysis,” JAMA, vol. 310, no. 16, pp. 1711-1720, 2013.
[3] A. Phrommintikul, et al., “Influenza vaccination reduces cardiovascular events in patients with acute coronary syndrome,” Eur. Heart J., vol. 32, no. 14, pp. 1730-1735, 2011.
[4] I. R. Mackay, “Tetanus toxoid: an immunomodulator?,” Med. Hypotheses, vol. 74, no. 4, pp. 688-691, 2010.
[5] T. Kawai, S. Akira, “The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors,” Nat. Immunol., vol. 19, no. 1, pp. 20-22, 2018.
[6] W. P. Glezen, et al., “The burden of influenza B: a structured literature review,” Am. J. Public Health, vol. 103, no. 3, pp. e43-e51, 2013.
[7] M. Rudolf, et al., “Pneumonia vaccination and cardiovascular events: a meta-analysis,” Chest, vol. 154, no. 3, pp. 641-652, 2018.
[8] L. A. Jackson, et al., “Pneumococcal vaccination and risk of cardiovascular events in men,” JAMA, vol. 310, no. 14, pp. 1466-1474, 2013.
[9] C. R. MacIntyre, et al., “Influenza vaccine as a coronary intervention for prevention of myocardial infarction,” Heart, vol. 102, no. 24, pp. 1953-1956, 2016.
[10] Centers for Disease Control and Prevention, “Behavioral Risk Factor Surveillance System (BRFSS) 2022 Data,” Available from: https://www.cdc.gov/brfss/annual_data/annual_2022.html.
[11] D. Mozaffarian et al., “Heart disease and stroke statistics—2016 update: a report from the American Heart Association,” Circulation, vol. 133, no. 4, pp. e38-e360, 2016.
[12] H. H. Kyu, et al., “Physical activity and risk of cardiovascular disease, cancer, and all-cause mortality,” Lancet, vol. 388, no. 10051, pp. 1302-1310, 2016.
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