Research Progress and Potential Applications of Bacteriocins in the Food Industry

Authors

  • Zhenghao Wang

DOI:

https://doi.org/10.61173/d68xff40

Keywords:

Bacteriocins, lactic acid bacteria, lanolin an-tibiotics, colicin

Abstract

Bacteriocins represent a class of secondary metabolites consisting of short peptides with potent bacteriostatic activity and are derived from both Gram-positive and Gram-negative bacterial species. Currently, they are under intense scrutiny in the scientific community. Historically, limited research on bacteriocins, coupled with insufficient understanding of their toxicity signatures and mode of action, has hampered the exploration of antimicrobial resistance. However, recent breakthrough discoveries and validations related to the taxonomic, biosynthetic, and mechanistic foundations of bacteriocins have significantly advanced the development of this field, laying a solid foundation for their development in food preservation, medical, and biological applications. In this comprehensive review, the aim is to present the current status of bacteriocin sources, their different classification schemes, and the complex mechanisms that underpin their biological activity. In addition, this review provides promising avenues for the future application of bacteriocins in the food industry, the medical sector, and the biological sciences, highlighting their potential to revolutionize these fields.

References

[1] Richards VP, Velsko IM, Alam MT, Zadoks RN, Manning SD, Pavinski Bitar PD et al. Population gene introgression and high genome plasticity for the zoonotic pathogen Streptococcus agalactiae. Molecular Biology and Evolution, 2019, 36: 2572- 2590.

[2] Dobson, A., Cotter, P. D., Ross, R. P., Hill, C. Bacteriocin production: a probiotic trait? Applied and Environmental Microbiology, 2012, 78(1): 1-6.

[3] Lü, X., Yi, L., Dang, J., Dang, Y., Liu, B. Purification of novel bacteriocin produced by Lactobacillus coryniformis MXJ 32 for inhibiting bacterial foodborne pathogens including antibiotic-resistant microorganisms. Food Control, 2014, 46: 264-271.

[4] Yi, Lanhua, et al. Purification and characterization of a novel bacteriocin produced by Lactobacillus crustorum MN047 isolated from koumiss from Xinjiang, China. Journal of Dairy Science, 2016, 99(9): 7002-7015.

[5] Zhang Yanan, Ji Xuewei, Song Lili, et al. Research and Dean&Francis ISSN 2959-409X application progress of bacteriocins. China Feed, 2024: 1-7.

[6] Pizarro-Cerda J, Cossart P. Microbe Profile: Listeria monocytogenes: a paradigm among intracellular bacterial pathogens. Microbiology (Reading), 2019, 165(7): 719-721.

[7] Negash, Abebe Worku, Berhanu Andualem Tsehai. Current applications of bacteriocin. International Journal of Microbiology, 2020.

[8] Sharma, K., Kaur, S., Singh, R., Kumar, N. Classification and mechanism of bacteriocin-induced cell death: A review. Journal of Microbiology, Biotechnology and Food Sciences, 2021, 11: e3733.

[9] Solis-Balandra, Miguel Angel, Jose Luis Sanchez-Salas. Classification and multi-functional use of bacteriocins in health, biotechnology, and food industry. Antibiotics, 2024, 13(7): 666.

[10] Pérez-Ramos A, Madi-Moussa D, Coucheney F, Drider D. Current knowledge of the mode of action and immunity mechanisms of LAB-bacteriocins. Microorganisms, 2021, 9(10): 2107.

[11] Uzelac, G., Miljkovic, M., Lozo, J., Radulovic, Z., Tosic, N., Kojic, M. Expression of bacteriocin LsbB is dependent on a transcription terminator. Microbiological Research, 2015, 179: 45-53.

[12] Kumariya, Rashmi, et al. Bacteriocins: Classification, synthesis, mechanism of action and resistance development in food spoilage-causing bacteria. Microbial Pathogenesis, 2019, 128: 171-177.

[13] Miceli de Farias, Felipe, et al. Raffinocyclicin is a novel plasmid-encoded circular bacteriocin produced by Lactococcus raffinolactis with broad-spectrum activity against many gram-positive food pathogens. Applied and Environmental Microbiology, 2024, 90(9): e0080924.

[14] Ludwig KC, Puls JS, Matos de Opitz CL, Innocenti P, Daniel JM, Bornikoel J, et al. The dual mode of antibacterial action of the synthetic small molecule DCAP involves lipid II binding. Journal of the American Chemical Society, 2024, 146(36): 24855-24862.

[15] Marković, Katarina G, et al. Colicins and microcins produced by Enterobacteriaceae: Characterization, mode of action, and putative applications. International Journal of Environmental Research and Public Health, 2022, 19(18): 11825.

[16] Singh, Veer Pal. Recent approaches in food biopreservation: A review. Open Veterinary Journal, 2018, 8(1): 104-111.

[17] Barbosa, Ana Andréa Teixeira, et al. Bacteriocins from lactic acid bacteria and their potential in the preservation of fruit products. Critical Reviews in Biotechnology, 2017, 37(7): 852- 864.

[18] Sugrue, Ivan, et al. Bacteriocin diversity, function, discovery and application as antimicrobials. Nature Reviews Microbiology, 2024, 22(9): 556-571.

[19] Su Jifeng, Shi Bin. Research progress on the effect of antibiotics on intestinal microbiota and metabolism. Chinese Journal of Microecology, 2024, 36(07): 855-859.

[20] Goh, K.S., Ng, Z.J., Halim, M., et al. A comprehensive review on the anticancer potential of bacteriocin: Preclinical and clinical studies. International Journal of Peptide Research and Therapeutics, 2022, 28: 75.

[21] Baindara P, Korpole S, Grover V. Bacteriocins: Perspective for the development of novel anticancer drugs. Applied Microbiology and Biotechnology, 2018, 102(24): 10393–10408.

[22] Teiar, Radja, et al. Enterocin DD14 can inhibit the infection of eukaryotic cells with enveloped viruses. Archives of Microbiology, 2024, 206(6): 269.

Downloads

Published

2025-06-26