A comprehensive review of CO2 laser treatment for oral leukoplakia

Authors

  • Kefan Wu

DOI:

https://doi.org/10.61173/vmzd0k90

Keywords:

CO2 laser, Oral leukoplakia, Treatment, Sur-gery

Abstract

Oral leukoplakia, also known as oral mucosal leukoplakia or oral leukoplakia, is a common oral disease characterized by patchy lesions of white or grayish white keratinization on the oral mucosa, it is recognized by the World Health Organization (WTO) as a precancerous oral mucosal disease, which has significant implications for its treatment. Carbon dioxide (CO2) laser refers to a laser that uses carbon dioxide gas as the working medium and has been widely used in oral mucosal diseases in recent decades, including oral leukoplakia. As an advanced medical technology, CO2 laser plays an important role in the field of medicine. This comprehensive review delves deeply into the intricate principles, multifaceted advantages and disadvantages, intricate operation methods, as well as the promising prospects of CO2 laser treatment for oral leukoplakia by meticulously examining and synthesizing relevant scientific literatures, to provide clinicians and researchers with a comprehensive and scientifically sound guideline for the treatment of oral leukoplakia.

References

[1] Asnaashari m, Behnam Roudsari m, Shirmardi m s. Evaluation of the Effectiveness of the Carbon Dioxide (CO2) Laser in Minor Oral Surgery: A Systematic Review: CO2 laser and minor oral surgery. Journal of Lasers in Medical Sciences, 2023, 14: e44.

[2] Gross a j, Herrmann t r w. History of lasers. World Journal of Urology, 2007, 25(3): 217-200.

[3] Choy d s. History of lasers in medicine.The Journal of Thoracic and Cardiovascular Surgery, 1988, 36 Suppl 2: 114- 117.

[4] Mogedas-Vegara a, Hueto-Madrid j a, Chimenos-Kustner e, Bescos-Atin c. The treatment of oral leukoplakia with the CO2 laser: A retrospective study of 65 patients. Journal Of Cranio- Maxillofacial Surgery, 2015, 43(5): 677-681.

[5] Patel c k n. Interpretation of CO2Optical Maser Experiments. Physical Review Letters, 1964, 12(21): 588-590.

[6] Klämpfl f. Physical Fundamentals [m]//Stübinger s, Klämpfl f, Schmidt m, Zeilhofer h-f. Lasers in Oral and Maxillofacial Surgery. Cham; Springer International Publishing. 2020: 3-8.

[7] Coluzzi d j. An overview of laser wavelengths used in dentistry. Dental Clinics of North America, 2000, 44(4): 753- 765.

[8] Strauss r a. Lasers in oral and maxillofacial surgery. Dental Clinics of North America, 2000, 44(4): 851-873.

[9] Axéll t, Pindborg j j, Smith c j, et al. Oral white lesions with special reference to precancerous and tobacco-related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18–21 1994. Journal of Oral Pathology & Medicine, 1996, 25(2): 49-54.

[10] Evren i, Brouns e r, Poell j b, et al. Associations between clinical and histopathological characteristics in oral leukoplakia. Oral Diseases, 2023, 29(2): 696-706.

[11] Speight p m, Khurram s a, Kujan o. Oral potentially malignant disorders: risk of progression to malignancy. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2018, 125(6): 612-627.

[12] Brouns e, Baart j, Karagozoglu k, et al. Treatment results of CO2 laser vaporisation in a cohort of 35 patients with oral leukoplakia. Oral Diseases, 2013, 19(2): 212-216.

[13] Mortazavi h, Safi y, Baharvand m, et al. Oral White Lesions: An Updated Clinical Diagnostic Decision Tree. Dentistry Journal, 2019, 7(1).

[14] Onda t, Hayashi k, Katakura a, Takano m. Oral leukoplakia and oral cancer. Cleveland Clinic Journal of Medicine, 2023, 90(2): 79-80.

[15] Holmstrup p, Dabelsteen e. Oral leukoplakia—to treat or not to treat. Oral Diseases, 2016, 22(6): 494-497.

[16] Tambuwala a, Sangle a, Khan a, Sayed a. Excision of Oral Leukoplakia by CO2 Lasers Versus Traditional Scalpel: A Comparative Study.British Journal Of Oral & Maxillofacial Surgery, 2014, 13(3): 320-327.

[17] Natekar m, Raghuveer h p, Rayapati d k, et al. A comparative evaluation: Oral leukoplakia surgical management using diode laser, CO2 laser, and cryosurgery. Journal of Clinical and Experimental Dentistry, 2017, 9(6): e779-e784.

[18] Chainani-Wu n, Lee d, Madden e, et al. Clinical predictors of oral leukoplakia recurrence following CO₂ laser vaporization. Journal of Cranio-Maxillofacial Surgery, 2015, 43(9): 1875-18879.

[19] Asnaashari m, Behnam Roudsari m, Shirmardi m s. Evaluation of the Effectiveness of the Carbon Dioxide (CO2) Laser in Minor Oral Surgery: A Systematic Review.Journal of Cranio-Maxillofacial Surgery, 2023, 14: e44.

[20] Sutter e, Giacomelli-Hiestand b, Rücker m, Valdec s. CO2 laser application in stomatology. Swiss Dental Journal, 2019, 129(3): 214-215.

[21] Galletta v, Azevedo l, Lodi g, Migliari d. Factors affecting Clinical Outcomes after Treatment of Oral Leukoplakia with CO(2) and Diode Laser. The Journal of Contemporary Dental Practice, 2017, 18(9): 775-780.

[22] Renapurkar s, Strauss r a. Lasers in Oral and Maxillofacial Surgery [M]. Oral and Maxillofacial Surgery for the Clinician. 2021: 817-830.

[23] Chu f w, Silverman s, Jr., Dedo h h. CO2 laser treatment of oral leukoplakia. Laryngoscope, 1988, 98(2): 125-130.

[24] Van Der Hem p s, Nauta j m, Van Der Wal j e, Roodenburg j l. The results of CO2 laser surgery in patients with oral leukoplakia: a 25 year follow up. Oral Oncology, 2005, 41(1): 31-37.

[25] Van Der Waal i. Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncology, 2009, 45(4-5): 317-323.

[26] López-Jornet p, Camacho-Alonso f. Comparison of pain and swelling after removal of oral leukoplakia with CO₂ laser and cold knife: a randomized clinical trial.Medicina Oral Patologia Oral y Cirugia Buca, 2013, 18(1): e38-44.

[27] Kaminer r, Liebow c, Margarone j e, 3rd, Zambon j j. Bacteremia following laser and conventional surgery in hamsters. Journal Of Oral And Maxillofacial Surgery, 1990, Dean&Francis Kefan Wu 48(1): 45-48.

[28] Zeinoun t, Nammour s, Dourov n, et al. Myofibroblasts in healing laser excision wounds. Lasers in Surgery and Medicine, 2001, 28(1): 74-79.

[29] Huang z, Wang y, Liang q, et al. The application of a carbon dioxide laser in the treatment of superficial oral mucosal lesions.Journal of Craniofacial Surgery, 2015, 26(3): e277-279.

[30] Campos w g, Esteves c v, Gallo c b, et al. Treatment of oral leukoplakia with CO2 laser (10,600 nm): analysis of 37 cases. Brazilian Oral Research, 2022, 36: e014.

[31] Ishii j, Fujita k, Komori t. Laser surgery as a treatment for oral leukoplakia. Oral Oncology, 2003, 39(8): 759-769. [ 3 2 ] C r i c h t o n n . Vi s u a l a n a l o g u e s c a l e ( VA S ) . Journal of Clinical Nursing, 2001, 10(5): 706-706.

[33] Warnakulasuriya s, ARIYAWARDANA A. Malignant transformation of oral leukoplakia: a systematic review of observational studies. Journal of Oral Pathology & Medicine, 2016, 45(3): 155-166.

[34] Yao y, Shen x, Shi l, et al. The combination of photodynamic therapy and fractional CO(2) laser for oral leukoplakia: Case series. Photodiagnosis and Photodynamic Therapy, 2020, 29: 101597.

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Published

2025-06-26