A Hypothesis for Diagnosis of Chronic Myeloid Leukemia based on miR-15a

Authors

  • Rui Huang
  • Yishi Yan

DOI:

https://doi.org/10.61173/1ejnkg12

Keywords:

-chronic myeloid leukemia (CML), miR-15a, Morgana, diagnosis

Abstract

Chronic myeloid leukemia (CML) is a type of leukemia characterized by myeloid proliferation. Morgana is a chaperone protein, whose levels are lower due to the overexpression of miR-15a in CP phase. By quantitatively detecting miR-15a and Morgana, we could verify the correlation of them to CP-CML, thus as biomarkers of CP-CML diagnosis.

References

[1] Rudolf Virchow (1821–1902). CA Cancer J. Clin. 1975, 25, 91-92. Dean&Francis

[2] Bennett J.H. Case of Hypertrophy of the Spleen and Liver, which Death Took Place from Suppuration of the Blood. Edinb. Med. Surg. J. 1845, 413-423.

[3] Jabbour E, Kantarjian H. Chronic myeloid leukemia: 2025 update on diagnosis, therapy, and monitoring. Am. J. Hematol. 2024; 1-22.

[4] Definition of Philadelphia Chromosome-NCI Dictionary of Cancer Terms-NCI. Available online: https://www.cancer. gov/publications/dictionaries/cancer-terms/def/philadelphiachromosome

[5] Faderl S, Talpaz M, Estrov Z, et al. The biology of chronic myeloid leukemia. N. Engl. J. Med. 1999 Jul 15;341(3):164-72.

[6] Khoury J.D., Solary E., Abla O. et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia 36, 1703-1719 (2022).

[7] Shah N.P., Bhatia R., Altman J.K. et al. Chronic Myeloid Leukemia, Version 2.2024. J. Natl. Compr. Canc. Netw. 2024;22(1):43-69.

[8] Ogasawara A, Matsushita H, Tanaka Y, et al. A simple screening method for the diagnosis of chronic myeloid leukemia using the parameters of a complete blood count and differentials. Clin. Chim. Acta. 2019 Feb;489:249-253.

[9] Poggio P., Rocca S., Fusella F. et al. miR-15a targets the HSP90 co-chaperone Morgana in chronic myeloid leukemia. Sci. Rep. 14, 15089 (2024).

[10] Front. Bioeng. Biotechnol., bringing microRNAs to light: methods for microRNA quantification and visualization in live cells, 18 January 2021, Sec. Synthetic Biology, Volume 8 – 2020.

[11] Penfornis, P., Fernandes, J.D., Pochampally, R.R. Polycomb group protein Suz12 is regulated by a novel miRNA-like small RNA. Sci. Rep. 8, 1720 (2018).

[12] BD®Cytometric Bead Array Solution. (2024) BD Biosciences. https://www.bdbiosciences.com/en-us/products/ reagents/immunoassays/cba

[13] National Human Genome Research Institute. (2024) Fluorescence In Situ Hybridization (FISH). https://www.genome. gov/genetics-glossary/Fluorescence-In-Situ-Hybridization

[14] Rozanova, S., Barkovits, K., Nikolov, M., et al. (2021). Quantitative Mass Spectrometry-Based Proteomics: An Overview. In: Marcus, K., Eisenacher, M., Sitek, B. (eds) Quantitative Methods in Proteomics. Methods in Molecular Biology, vol 2228. Humana, New York, NY.

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Published

2025-09-09

Issue

Vol. 3 No. 4 (2025): Volume 3, Issue 4

Section

Articles

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