Advances in Inorganic Nano Sunscreens for UV Protection and Biocompatibility Enhancement
DOI:
https://doi.org/10.61173/4qrrc426Keywords:
Inorganic nano sunscreen, ultraviolet pro-tection, nanoparticle dispersion, metal doping, sunscreen biocompatibilityAbstract
Excessive ultraviolet (UV) radiation increases skin disease risk, which is a global health issue. Sunscreen is an effective way to reduce UV radiation. While inorganic nano ZnO and TiO2 have occupied partial sunscreen market in recent years due to their high efficiency and good photostability, there is still improvement space in sunscreen efficiency, biological safety and customization. This paper reviews the recent literature on inorganic nano sunscreen modification. To improve sunscreen performance, the inorganic nanoparticles can be loaded on scaffold materials or doped with specific metal elements. For their biological safety, modification with certain natural polymers to eliminate reactive oxygen species (ROS) and the size/structure control to decrease skin penetration are effective. Adding dark-colored materials and skin-care materials to inorganic nano sunscreen formulations helps them better commercialization. However, most of these studies are still in the laboratory stage, requiring further research. Hopefully, more enhancement mechanisms and available modification materials are expected to be developed in the future.
References
[1] Urbach, F. The historical aspects of sunscreens. Journal of Photochemistry and Photobiology B: Biology, 2001, 64, 99-104.
[2] Ignasiak, M. T., Houée-Levin, C., Kciuk, G., Marciniak, B. & Pedzinski, T. A Reevaluation of the Photolytic Properties of 2-Hydroxybenzophenone-Based UV Sunscreens: Are Chemical Sunscreens Inoffensive? Chemphyschem, 2015, 16, 628-633.
[3] Xu, S., Kwa, M., Agarwal, A., Rademaker, A. & Kundu, R. V. Sunscreen Product Performance and Other Determinants of Consumer Preferences. Jama Dermatology, 2016, 152, 920-927.
[4] Morganti, P. Use and potential of nanotechnology in cosmetic dermatology. Clinical, Cosmetic and Investigational Dermatology, 2010, 3, 5-13.
[5] Cole, C., Shyr, T. & Ou-Yang, H. Metal oxide sunscreens protect skin by absorption, not by reflection or scattering. Photodermatology, Photoimmunology & Photomedicine, 2016, 32, 5-10.
[6] Egerton, T. A. & Tooley, I. R. UV absorption and scattering properties of inorganic-based sunscreens. International Journal of Cosmetic Science, 2012, 34, 117-122.
[7] Fu, P. P., Xia, Q., Hwang, H. M., Ray, P. C. & Yu, H. Mechanisms of nanotoxicity: generation of reactive oxygen species. Journal of Food and Drug Analysis, 2014, 22, 64-75.
[8] Wang, L., Cui, X. M., Dong, Q. Y., Liang, W. C. & Jin, H. J. A transparent kaolinite-loaded zinc oxide nanocomposite sunscreen with UV shielding rate over 99% based on bidirectional dispersion. Nanotechnology, 2023, 34, 075601.
[9] Yu, H. Z., Xie, J. X., Yao, L. & Yang, H. T. Fabrication of Microcrystalline cellulose and nano-titanium dioxide composites with broad-spectrum UV protection. Chemical Engineering Journal, 2025, 505, 159134.
[10] Rabani, I. et al. Titanium dioxide incorporated in cellulose nanofibers with enhanced UV blocking performance by eliminating ROS generation. RSC Advances, 2022, 12, 33653- 33665.
[11] Takekawa, S., Ohara, M., Banno, T. & Asakura, K. Factors to control the alignment of surface-treated titanium dioxide powders to maximize performance of sunscreens. International Journal of Cosmetic Science, 2023, 45, 38-49.
[12] Ansari, K., Riaz, R., Gull, F. & Atiq, H. Incorporation of zinc oxide and cobalt doped zinc oxide nano-rods in commercial sunscreen sample to optimize its UV-ray absorption. Physica Scripta, 2024, 99, 075051.
[13] Torbati, T. V. & Javanbakht, V. Fabrication of TiO2/ Zn2TiO4/Ag nanocomposite for synergic effects of UV radiation protection and antibacterial activity in sunscreen. Colloids and Surfaces B-Biointerfaces, 2020, 187, 110652.
[14] Li, Z. X., Tong, L., Ma, Y. Q. & Zhao, L. Fabrication of CeO2/CaO nanocomposite as ultraviolet screening agent and its application in sunscreen. Ceramics International, 2024, 50, 20431-20440.
[15] Hasnu, J. et al. Sustainable production of multifunctional NiO-CeO2 nano-heterostructures showing superior UV-B photoprotection with pronounced antioxidant and antimicrobial activity. Surfaces and Interfaces, 2025, 56, 105676.
[16] Qian, Y., Qiu, X. Q. & Zhu, S. P. Lignin: a nature-inspired sun blocker for broad-spectrum sunscreens. Green Chemistry, 2015, 17, 320-324.
[17] Yu, J. et al. Facile and Green Preparation of High UV- Blocking Lignin/Titanium Dioxide Nanocomposites for Developing Natural Sunscreens. Industrial & Engineering Chemistry Research, 2018, 57, 15740-15748.
[18] Dubey, A., Goswami, M., Yadav, K. & Chaudhary, D. Oxidative Stress and Nano-Toxicity Induced by TiO2 and ZnO on WAG Cell Line. PLOS One, 2015, 10, e0127493.
[19] Genç, H. et al. Biocompatibility of designed MicNo-ZnO particles: Cytotoxicity, genotoxicity and phototoxicity in human skin keratinocyte cells. Toxicology in Vitro, 2018, 47, 238-248.
[20] Liang, Y. et al. Antagonistic Skin Toxicity of Co-Exposure to Physical Sunscreen Ingredients Zinc Oxide and Titanium Dioxide Nanoparticles. Nanomaterials, 2022, 12(16), 2769.
[21] Ghiazza, M. et al. Inhibition of the ROS-mediated cytotoxicity and genotoxicity of nano-TiO2 toward human keratinocyte cells by iron doping. Journal of Nanoparticle Research, 2014, 16, 2263.
[22] Zheng, X. D. et al. Phycocyanin- and Polydopamine- Conjugated Titania Nanoparticles for UV Protection. ACS Applied Nano Materials, 2025, 8, 6983-6993.
[23] Li, Y. Y. et al. Encapsulating TiO2 in Lignin-Based Colloidal Spheres for High Sunscreen Performance and Weak Photocatalytic Activity. ACS Sustainable Chemistry & Engineering, 2019, 7, 6234-6242.
[24] Wei, L. Y. et al. ZnO/Dealkali Lignin Composite Nanosheet for Antiultraviolet and Antioxidant Applications. ACS Applied Nano Materials, 2025, 8(6), 3244-3253.
[25] Arya, A., Gangwar, A., Singh, S. K. & Bhargava, K. Polyethylene glycol functionalized cerium oxide nanoparticle confer protection against UV- induced oxidative damage in skin: evidences for a new class of UV filter. Nano Express, 2020, 1, 010038.
[26] Lyons, A. B., Trullas, C., Kohli, I., Hamzavi, I. H. & Lim, H. W. Photoprotection beyond ultraviolet radiation: A review Dean&Francis Xinyu Qi of tinted sunscreens. Journal of the American Academy of Dermatology, 2021, 84, 1393-1397.
[27] Zhang, J. L. et al. Tint-Adjustable Pickering Emulsion Sunscreen Based on Polydopamine-Coated Silica Nanoparticles. ACS Applied Nano Materials, 2024, 7, 15365-15375.
[28] Badalkhani, O. et al. Nanogel Containing Gamma- Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/ MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection. Pharmaceuticals, 2023, 16(5), 670.
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