Application of Hydrogels in Tissue Engineering and Future Development Trends
DOI:
https://doi.org/10.61173/xg40fd79Keywords:
Hydrogel, tissue engineering, smart materi-als, clinical translationAbstract
This study investigates the application of hydrogels in tissue engineering, emphasizing their significance and potential within the field. Initially, the basic properties and classifications of hydrogels are described to establish a theoretical foundation for subsequent discussions. The current applications of hydrogels in the repair and regeneration of various tissues, including bones, skin, and nerves, are analyzed in detail. This analysis highlights the challenges and technological bottlenecks faced by existing applications, such as insufficient mechanical properties and difficulties in controlling degradation rates. Furthermore, the research explores future development trends of hydrogels in tissue engineering, focusing on the integration of smart materials, nanotechnology, and environmentally responsive properties in advanced applications. The study concludes with an industrial analysis of the current state of hydrogel tissue engineering, outlining challenges for clinical translation. Overall, this study offers a comprehensive overview of hydrogels' applications in tissue engineering, providing valuable insights into the field's future development and significant theoretical and practical implications for promoting the application and clinical translation of hydrogels in tissue engineering.
References
active factors from degradation and prolong the half-life Advances in Colloid and Interface Science, 2025, 341: 103481. of the factors, and can achieve a slow release and pulsed [2] CHEN T, JIANG Y, HUANG J-P, et al. Essential elements for release of the drugs. These systems have a number of ad- spatiotemporal delivery of growth factors within bio-scaffolds: vantages that protect the bioactive factors from degrada- A comprehensive strategy for enhanced tissue regeneration.
tion and extend their half-life, allow for slow and pulsed Journal of Controlled Release, 2024, 368: 97-114. release of the drug, and can cross biological barriers and [3] ZHOU X, WANG Z, LI T, et al. Enhanced tissue infiltration deliver the drug to the target tissues with precision. Stud- and bone regeneration through spatiotemporal delivery of ies have shown that the effective duration of action of bioactive factors from polyelectrolytes modified biomimetic
growth factors in nano-hydrogel carriers can be extended scaffold. Materials Today Bio, 2023, 20: 100681. Dean&Francis ISSN 2959-409X [4] LI G, LUO Y, HU Z, et al. Recent Advances in Peptide- [9] ZHANG K, SIMIC R, SPENCER N D. Imparting ultralow Functionalized Hydrogels for Bone Tissue Engineering. ACS lubricity to double-network hydrogels by surface-initiated
Biomaterials Science & Engineering, 2025, 11(4): 1970-89. controlled radical polymerization under ambient conditions. [5] PENG Y-Y, CHENG Q, WU M, et al. Highly Stretchable, Biotribology, 2021, 26: 100161. Self-Healing, Injectable and pH Responsive Hydrogel from [10] ZHONG L, ZHANG Y, LIU F, et al. Muscle-inspired Multiple Hydrogen Bonding and Boron-Carbohydrate anisotropic carboxymethyl cellulose-based double-network
Interactions. Gels, 2023, 9(9): 709. conductive hydrogels for flexible strain sensors. International [6] JIANG Y, GUO S, JIAO J, et al. A Biphasic Hydrogel with Journal of Biological Macromolecules, 2023, 248: 125973. Self-Healing Properties and a Continuous Layer Structure for [11] ZHANG H, TAKEZAWA A, DING X, et al. Bi-material Potential Application in Osteochondral Defect Repair. Polymers, microstructural design of biodegradable composites using 2023, 15(12): 2744. topology optimization. Materials & Design, 2021, 209: 109973. [7] WANG Y, CAO X, MA M, et al. A GelMA-PEGDA-nHA [12] ALGHAMDI N S, RANA M, PENG X, et al. Zinc– Composite Hydrogel for Bone Tissue Engineering. Materials, Bromine Rechargeable Batteries: From Device Configuration, 2020, 13(17): 3735. Electrochemistry, Material to Performance Evaluation. Nano- [8] NASRA S, PATEL M, SHUKLA H, et al. Functional Micro Letters, 2023, 15(1). hydrogel-based wound dressings: A review on biocompatibility
and therapeutic efficacy. Life Sciences, 2023, 334: 122232.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 by the authors.
This work is licensed under a Creative Commons Attribution 4.0 International License.
