The application and evaluation of pericyclic reactions in the industrial synthesis of medicines and alkaloids
DOI:
https://doi.org/10.61173/vrwjna64Keywords:
Pericyclic reaction, Industrial drug synthe-sis, Alkaloids, Large-scale productionAbstract
The research is based on the development of the pericyclic reaction which has been discovered effectively in the production of clinical drugs. People has increasingly noticed that it can increase the purity of the final product and have paid attention to applying it in further synthesis. The research aims to evaluate whether the pericyclic reaction can be used in large-scale production for relative medicines or alkaloids and whether it is possible to use it in medicines with other structures. Essentially, all the research is supported by secondary research, and the samples are sourced from relevant previous analyses. The researcher uses the samples and databases and compares them to illustrate the benefits and hidden drawbacks of the pericyclic reaction. After discussion, the researcher concludes that the pericyclic reaction can be widely applied if the structure of the substance meets the reaction’s requirements, enabling large-scale synthesis of appropriately structured medicines or alkaloids.
References
Alvarez, R. and Angel (2021). Correction: Natural polyenic macrolactams and polycyclic derivatives generated by transannular pericyclic reactions: optimized biogenesis challenging chemical synthesis. Natural Product Reports, 38(6), pp.1221-1225. doi:https://doi.org/ 10.1039/d1np90001c.
Alvarez, R. and de Lera, A.R. (2021). Natural polyenic macrolactams and polycyclic derivatives generated by transannular pericyclic reactions: optimized biogenesis challenging chemical synthesis. Natural Product Reports, 38(6), pp.1136-1220. doi:https://doi.org/10.1039/d0np00050g. Corti, M., Chiara, R., Romani, L., Mannucci, B., Malavasi,
L. and Quadrelli, P. (2020) ‘g-C₃N₄/Perovskite Composites as Photocatalysts for Singlet Oxygen Generation’, in Foschi, F. and Pirovano, V. (eds.) 1st Virtual Symposium on Pericyclic Reactions and Synthesis of Carbo- and Heterocyclic Systems, pp. 1–34.
Diels, O. and Alder, K. (1928). Synthesen in der hydroaromatischen Reihe. Justus Liebig’s Annalen der Chemie, 460(1), pp.98-122. doi:https://doi.org/10.1002/ jlac.19284600106.
Faita, G., Leusciatti, M. and Paolo, O. (2022). Synthesis and biological activity ofpotential antiviral compounds through 1,3-dipolar cycloadditions; Part 1: general aspects and reactions of azides. ARKIVOC, 2022(8), pp.19-78. doi:https://doi. org/10.24820/ark.5550190.p011.794.
Foschi, F. and Pirovano, V. (2015). st Virtual Symposium on Pericyclic Reactions and Synthesis of Carbo-and Heterocyclic Systems. [online] Available at: https://cirp.unime.it/wp-content/ uploads/sites/41/2015/05/book-of-abstract_compresse d-1.pdf. Gagarin, A.A., Suntsova, P.O., Minin, A.S., Pozdina, V.A.,
Slepukhin, P.A., Benassi, E. and Belskaya, N.P. (2020). Two Approaches for the Synthesis of Fused Dihydropyridines via a Dean&Francis ISSN 2959-409X 1,6-Electrocyclic Reaction: Fluorescent Properties and Prospects for Application. The Journal of Organic Chemistry, 85(21), pp.13837-13852. doi:https://doi.org/10.1021/acs.joc.0c01934.
Hoffmann, R. and Woodward, R.B. (1965). Orbital Symmetries and endo-exo Relationships in Concerted Cycloaddition Reactions. Journal of the American Chemical Society, 87(19), pp.4388–4389. doi:https://doi.org/ 10.1021/ja00947a033.
Kai and Stryker, J.M. (2013). ChemInform Abstract: [5+2] Cycloaddition Reactions in Organic and Natural Product Synthesis. Chemical Reviews 113(3), pp. 2244-2266. doi:https:// doi.org/10.1002/chin.201319242.
Michael and Jie, C. (1992). Mechanisms ofpericyclic reactions: the role ofquantitative theory in the study of reaction mechanisms. Accounts of Chemical Research, 25(11), pp.537- 543. doi:https://doi.org/ 10.1021/ar00023a008.
Nemoto, H. (2007). Synthetic Organic Chemistry Based on Small Ring Compounds. Chemical and Pharmaceutical Bulletin, 55(7), pp. 961-974. doi:https://doi.org/ 10.1002/chin.200748230.
Pasteur, L. (1848). Sur les relations qui peuvent exister entre la forme crystalline, la composition chimique et le sens de la polarization rotatoire. Annales Chimie Phys., [online] 24, pp.442- 459. Available at: https://cir.nii.ac.jp/crid/1571417124719940608 [Accessed 9 Mar. 2025].
Quadrelli, P., Mella, M. and Faita, G. (2023). Synthesis and Biological Activity of Potential Antiviral Compounds Through 1,3-Dipolar Cycloadditions; Part 2: Nitrones, Nitrile Oxides and Imines, and Other 1,3-Dipoles. Arkivoc, 2022(8), pp.257-294. doi:https://doi.org/10.24820/ark.5550190.p011.896.
So, S.M., Mui, L., Kim, H. and Chin, J. (2012). Understanding the Interplay of Weak Forces in [3,3]-Sigmatropic Rearrangement for Stereospecific Synthesis of Diamines. Accounts of Chemical Research, 45(8), pp.1345-1355. doi:https://doi.org/10.1021/ ar2002842.
Yin, Y., Wang, J. and Li, J. (2024). A concise and scalable chemoenzymatic synthesis of prostaglandins. Nature Communications [online] 15(1), p.2523. doi:https://doi. org/10.1038/s41467-024-46960-y.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 by the authors.
This work is licensed under a Creative Commons Attribution 4.0 International License.
