Analysis of the effect on immune recognition of the glycosylation of viral envelope based on the analysis of the HIV-1 envelope

Abstract

This passage firstly presents the global overview of the Human immunodeficiency virus (HIV), then providing a comprehensive review of the difficulties in the development of vaccines against the HIV, focusing on glycosylation modification of the envelope protein. During the infection process of this virus, the glycosylation modification help the virus evade the monitoring of the immune system through a series of immune evasion mechanisms. The glycosylation modifications of the virus are mainly located on the envelope of the virus. During the formation process of the envelope, the core products Group-specific antigen exerts a vital influence and shows positive effects in the maturation of the surface envelope proteins. Also, the components of the viral envelope and the mechanisms of glycosylation are introduced. The envelope protein have a significant impact in the immune evasion. Also, the passage introduces the recent progress in the research on treatment for the virus. An overall review on the impact of glycosylation modifications on immune evasion mechanism of HIV-1 virus is helpful for the future research in this field.