Time-Restricted Feeding as a Circadian Therapeutic Strategy for Alzheimer’s Disease

Abstract

Time-Restricted Feeding (TRF), a form of intermittent fasting, has been recognized as a promising nonpharmacological intervention for improving circadian rhythms and metabolic health. Given the critical role of circadian rhythm disruption in Alzheimer’s disease (AD) pathogenesis, TRF is gaining increasing attention as a potential strategy for mitigating AD pathology. This review examines the biological mechanisms through which TRF influences AD-related processes, including circadian rhythms, amyloid-β deposition, tau pathology, and neuroinflammation. Animal studies demonstrate that TRF enhances neuronal resistance, improves synaptic plasticity, and modulates AD-associated metabolic pathways. Concurrently, clinical research suggests TRF may improve sleep architecture and cognitive function, though challenges remain regarding adherence and long-term efficacy. By integrating animal and human studies, this review highlights TRF’s multiple roles in AD prevention and treatment. Notably, TRF serves not only as a circadian rhythm-based lifestyle intervention but also as a potential significant adjunct strategy in AD therapy. Future directions include conducting long-term clinical trials and developing personalized treatment plans based on individual genotypes and chronotypes to maximize therapeutic benefits.