The Mechanism and Intervention Strategies of Non-Alcoholic Fatty Liver Disease Caused by High-Fructose Beverages in Adolescents
DOI:
https://doi.org/10.61173/e0m3mv36Keywords:
Non-alcoholic fatty liver disease, Adolescents, High-fructose beverages, Metabolic complications, Intervention strategiesAbstract
There is a common chronic liver disease among adolescents, called non-alcoholic fatty liver disease. It is common among teenagers all over the world. This kind of liver disease is difficult to detect in the early stage, and the symptoms are not obvious, but long-term development will lead to liver evolution. And this liver disease can lead to insulin resistance and metabolic complications. However, the current medical direction is mainly targeted at adults, and there is still a lack of research on the causes and prevention mechanisms of adolescents. In fact, the liver metabolism of adolescents is very active, which will also lead to the immaturity of intestinal flora, so the mechanism of liver disease in adolescents is worth studying. This paper systematically introduced the prevalence of nonalcoholic fatty liver disease in adolescents and the data of high fructose intake, explained the relationship between high fructose intake and the incidence of nonalcoholic fatty liver disease, proposed intervention strategies at different levels for different age groups, analyzed the implementation problems faced by implementing these measures in reality, and summarized the possible research directions and prevention prospects in the future.
References
[1] Riazi K, et al. The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis. The Lancet Gastroenterology & Hepatology, 2022, 7(9): 851-861.
[2] Stanhope K L, Havel P J. Fructose consumption: recent results and their potential implications. Annals of the New York Academy of Sciences, 2010, 1190(1): 15-24.
[3] DiStefano J K, Shaibi G Q. The relationship between excessive dietary fructose consumption and paediatric fatty liver disease. Pediatric Obesity, 2020, 16(6): e12759.
[4] Younossi Z M, et al. Lifestyle interventions in nonalcoholic fatty liver disease. Nature Reviews Gastroenterology & Hepatology, 2023, 20(11): 708-722.
[5] Eng J M, Estall J L. Diet-induced models of non-alcoholic fatty liver disease: food for thought on sugar, fat, and cholesterol. Cells, 2021, 10(7): 1805.
[6] Wang H, Gan Q, Zhang Q. Research updates of international strategies to control sugar-sweetened beverages consumption in children and adolescents. Chinese Journal of School Health, 2021, 42(3): 471-476.
[7] Miller E F. Nutrition management strategies for nonalcoholic fatty liver disease: treatment and prevention. Clinical Liver Disease, 2020, 15(4): 144-148.
[8] Ahmed I A, et al. Lifestyle interventions for non-alcoholic fatty liver disease. Saudi Journal of Biological Sciences, 2019, 26(7): 1519-1524.
[9] Cogorno L, et al. Non-alcoholic fatty liver disease: dietary and nutraceutical approaches. Liver Research, 2023, 7(3): 216- 227.
[10] Lee Y, Kim H. Fructose metabolism and hepatic steatosis in adolescents: a review. Journal of Pediatric Gastroenterology and Nutrition, 2022, 75(4): 498-504.
[11] Zhang Y, et al. Gut microbiota dysbiosis and endotoxin/ TLR4 pathway in adolescent NAFLD associated with highfructose intake. Frontiers in Pediatrics, 2021, 9: 689234.
[12] Chen J, et al. Hyperuricemia as a mediator of fructoseinduced NAFLD in adolescents. Pediatric Research, 2020, 88(3): 567-573.
[13] Liu X, et al. School-based interventions for reducing highfructose beverage intake and preventing NAFLD in adolescents. Health Education Research, 2022, 37(2): 189-198.
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