The Impact of the Mediterranean Diet on Coronary Heart Disease

Authors

  • Yuhang Sun

DOI:

https://doi.org/10.61173/amrkwq12

Keywords:

Coronary heart disease, Mediterranean diet, Cardiovascular disease

Abstract

Coronary artery disease (CAD) ranks among the most prevalent and deadly cardiovascular conditions globally. Lately, an observable trend shows that CAD is increasingly impacting younger people. This article aims to study the relationship between the unique nutrients in the Mediterranean diet (MeDi) and CAD, so as to achieve its prevention and adjuvant treatment effect, and provides more feasible schemes for the alleviation of CAD. This paper reviews the potential mechanism of the key nutrients in the MeDi in the prevention and adjuvant treatment of CAD by systematically consulting and summarizing the relevant literature at home and abroad. The results show that the MeDi through its special nutrients (such as oleic acid, polyphenols, ω -3 Polyunsaturated fatty acids, plant proteins, etc.) have multi-target, multi-channel effects and their synergistic effects in regulating blood lipid metabolism, improving vascular endothelial function and other aspects of effective intervention on CAD, thus playing the role of intervention and adjuvant therapy on CAD.

References

[1] Chen XF, Li LZ. Protective effect of Mediterranean Diet on cardiovascular diseases. Modern Nurse (Mid-month Edition), 2014, (08): 1-4.

[2] Domínguez-López I, Galkina, P., Fernández-Duval, G. et al. Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial.

[3] Javier D, et al. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial . Lancet (London, England), 2022, 399(10338): 1876-1885.

[4] Feingold KR. The effect of diet on cardiovascular disease and lipid and lipoprotein levels. 2024 Mar 31. In: Feingold KR, Adler RA, Ahmed SF, Anawalt B, Blackman MR, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hamilton E, Hofland J, Jan de Beur S, Kalra S, Kaltsas G, Kapoor N, Kim M, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Muzumdar R, Purnell J, Rey R, Sahay R, Shah AS, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. PMID: 33945244.

[5] Chen B. Prevention and treatment of coronary heart disease from the perspective of clinical practice. Strait Science, 2020, (10): 64-67+72.

[6] Wang N. Mechanism of action of monounsaturated fatty acids on cardiovascular diseases. China Practical Medicine, 2010, 5(23): 256-257.

[7] Liu GS, Xu GF. Protective effects of monounsaturated fatty acids on cardiovascular system. Journal of Hygiene Research, 2006, (03): 357-359.

[8] Chang CP. Research progress and application status of phytosterols in cardiovascular diseases. Food and Nutrition in China, 2016, 22(06): 76-80.

[9] Xiu H L, Yang R Y, Dong J, et al. Polyphenolic biomarkers and cardiovascular diseases. Chinese Journal of Cardiology, 2015, 20(06): 477-479.

[10] Wu Q, Li HM, Yang CK, et al. Research progress on the protective mechanisms of resveratrol in cardiovascular diseases. China Journal of Chinese Materia Medica, 2025, 50(12): 3244- 3251.

[11] Zhao JY, Yao HZ, Li YQ, et al. Research progress on antiinflammatory activity of dietary phenolic compounds and their mechanisms in intervening inflammatory signaling pathways. Modern Food Science and Technology, 2024, 40(10): 398-408.

[12] Soliman GA. Dietary fiber, atherosclerosis, and cardiovascular disease. Nutrients, 2019, 11: 1155.

[13] Li SS, Blanco Mejia S, Lytvyn L, Stewart SE, Viguiliouk E, Ha V, de Souza RJ, Leiter LA, Kendall CWC, Jenkins DJA, Sievenpiper JL. Effect of plant protein on blood lipids: A systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc. 2017 Dec 20, 6(12): e006659.

[14] Zhao YJ, Liu Y, Zhang X, et al. Atherosclerosis antagonistic mechanisms of Omega-3 polyunsaturated fatty acid metabolites. Chinese Journal of Arteriosclerosis, 2020, 28(06): 461-467.

[15] Liang J, Wen Y, Yin J, Zhu G, Wang T. Utilization of plantbased foods for effective prevention of chronic diseases: a longitudinal cohort study. NPJ Sci Food. 2024 Dec 27, 8(1): 113.

[16] Elliott PS, Kharaty SS, Phillips CM. Plant-based diets and lipid, lipoprotein, and inflammatory biomarkers of cardiovascular disease: A review of observational and interventional studies. Nutrients 2022, 14, 5371.

[17] English C, Jones M, Lohning A, Mayr H, MacLaughlin H, Reidlinger D. Associations between food groups and biomarkers of inflammation: Are some foods groups more protective than others? Proceedings of the Nutrition Society. 2024, 83(OCE1): E189.

[18] Tucci M, Marino M, Martini D, Porrini M, Riso P, Del Bo’ C. Plant-based foods and vascular function: A systematic review of dietary intervention trials in older subjects and hypothesized mechanisms of action. Nutrients. 2022 Jun 24, 14(13): 2615.

[19] Berisha H, Hattab R, Comi L, Giglione C, Migliaccio S, Magni P. Nutrition and lifestyle interventions in managing dyslipidemia and cardiometabolic risk. Nutrients. 2025 Feb 23, 17(5): 776.

[20] Marrero AD, Quesada AR, Martínez-Poveda B, Medina MÁ. Anti-cancer, anti-angiogenic, and anti-atherogenic potential of key phenolic compounds from virgin olive oil. Nutrients, 2024, 16, 1283.

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Published

2026-04-24