Does Panax notoginseng (Sanqi) inhibit H22 tumor growth via improving the host’s cellular immunity?

Authors

  • Han Lin

DOI:

https://doi.org/10.61173/rgwmk379

Keywords:

ginsenoside, cellular immunity, cytokine, Ginsenoside, Rg3, Immunosuppression, stereoisomer, stereospecific, liver cancer

Abstract

Ginsenoside Rg3 has many functions, including anti-tumor activity, antioxidant activity, and immune system modulatory activity. Interestingly, There are two stereoisomers exist in Rg3, 20(S)-ginsenoside Rg3 [20(S)-Rg3] and 20(R)-ginsenoside Rg3 [20(R)-Rg3], respectively. These two isomers have different pharmacological effects due to their stereospecificity. In this study, we compared their effect of stimulating the ConA to induce lymphocyte proliferation and increase the cytokines IL-2 and IFN-γ levels in mice and improve the cellular immunity of the host. The study predicted that ginsenoside (Rg3) could increase Th1-type cytokines interleukin-2 and interferon-γ and stimulate ConA-induced lymphocyte proliferation in mice, thereby improving cellular immunity in H22 mice. The effects of the Rg3 R-form were significantly greater than Rg3 S-form.

References

[1] Wang, C.-Z., McEntee, E., Wicks, S., Wu, J.-A., and Yuan, C.-S. (2006). Phytochemical and analytical studies of Panax notoginseng (Burk.) F.H. Chen. J. Nat. Med. 60, 97–106. doi: 10.1007/s11418-005-0027-x

[2] Shi, X., Yu, W., Yang, T., Liu, W., Zhao, Y., Sun, Y., et al. (2016). Panax notoginseng saponins provide neuroprotection by regulating NgR1/RhoA/ ROCK2 pathway expression, in vitro and in vivo. J. Ethnopharmacol. 190, 301–312. doi: 10.1016/ j.jep.2016.06.017

[3] Peng M, Yi YX, Zhang T, Ding Y and Le J (2018) Stereoisomers of Saponins in Panax notoginseng (Sanqi): A Review. Front. Pharmacol. 9:188. doi: 10.3389/ Dean&Francis fphar.2018.00188

[4] Wu, R., Ru, Q., Chen, L., Ma, B., and Li, C. (2014). Stereospecificity of ginsenoside Rg3 in the promotion of cellular immunity in hepatoma H22-bearing mice. J. Food Sci. 79, H1430–H1435. doi: 10.1111/1750-3841.12518

[5] Liu,Y. Qin,H. Zhong,Y. Li,S. W,H. W,H. Chen,L. Tang,X and Li,Y(2021)Neutral polysaccharide from Panax notoginseng enhanced cyclophosphamide antitumor efficacy in hepatoma H22- bearing mice. BMC Cancer doi:https://doi.org/10.1186/s12885-020-07742-z

Downloads

Published

2023-06-01

Issue

Vol. 1 No. 1 (2023): Volume 1, Issue 1

Section

Articles

License

Copyright (c) 2023 by the authors.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.