Inhibitory effect of N-oxalylglycine on gastric cancer cells
DOI:
https://doi.org/10.61173/q0wmjb45Keywords:
gastric cancer, N-oxalylglycine (NOG), 2-oxoglutarate (2OG) oxygenase, orthotopic xenograft, cell culture, western blotAbstract
Some surveys have shown the possibility of controlling the growth of cancer cells by decreasing the content of 2OG
oxygenase with NOG. This research aims to supply the blank of whether the anti-cancer ability of NOG exists in vitro
and xenografted mice and how this ability is formed. Use human gastric cancer cell lines, SGC7901. They have brought
NOG, MTT, and cisplatin from different companies separately. Choose 60 male BALB/c Nude mice aged four weeks
with an average weight of 15 – 20g as the experimental subject. Measure killing by MTT assay and tumor shrinkage
in an SGC-7901 xenograft mouse and 2OG oxygenase by western blot. The possible results are: (1) NOG restrains
SGC7901 cells’ growth by inhibiting the abundance of 2OG oxygenase. (2) NOG can restrain the growth of SGC7901
cells, but the principle differs from inhibiting the abundance of 2OG oxygenase. (3) NOG cannot restrain the growth of
SGC7901 cells.
References
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