Does Astragalus Membranaceus Polysaccharides in Astragalus Mongholicus as One of Six Herbs in Bushen Formula Can Be Effective to Decrease the Hepatitis B Viral Load and Alanine Aminotransferase of CHB Patients?

Authors

  • Zhuocheng Yu

DOI:

https://doi.org/10.61173/6bpzb284

Keywords:

(APS), Hepatitis B, Hepatitis B Virus (HBV), Carbon tetrachloride (CCl4) induced-liver failure models, hydrodynamic injection, Ziziphus jujube fruit (FZJ)

Abstract

Hepatitis B was the most widespread viral disease and had a very high infection in China during the last 40 years of the 20th to 21st century. The traditional Chinese medicine Bushen formula can treat hepatitis B by lower the mildly elevated alanine aminotransferase and HBV DNA levels for patients. Previous research has shown that the organic compound Astragalus polysaccharide can increase the percentage of CD4+ and CD8+ lymphocyte subsets and reduce hepatic damage caused by chronic hepatitis B. This study investigates APS in treating mice’s hepatic injury by building a CCl4- induced liver failure model and CD4+ CD8+ lymphocyte subsets in peripheral blood analysis models.

References

[1] Beneficial therapeutic effect of Chinese herbal Bushen formula on CHB patients with mildly elevated alanine aminotransferase by down-regulating CD4þCD25þT cells by Man Li a,1, Xue-Hua Sun b,1, Zhen-Hua Zhou a, Zhuo Yu a, Shu-Gen Jin b, Xiao-Jun Zhu b, Yue-Qiu Gao a,b,n: http://dx.doi.org/10.1016/j.jep.2013.01.038

[2] Review: HEPATITIS B VIRUS INFECTION by WILLIAM M. LEE, M.D.

[3] Inhibitory effect of Huangqi Zhechong decoction on liver fibrosis in rat by Shuang-Suo Dang, Xiao-Li Jia, Yan-An Cheng, Yun-Ru Chen, En-Qi Liu, Zong-Fang Li

[4] Immunomodulatory and Antimicrobial Effects of Some Traditional Chinese Medicinal Herbs: A Review by Benny K.H. Tan* and J. Vanitha

[5] Review: Structural features and biological activities of the polysaccharides from Astragalus membranaceus by Mingliang Jina,1, Ke Zhaob,1, Qingsheng Huanga, Peng Shanga, ∗

[6] Protective effects of emodin and Astragalus polysaccharides on chronic hepatic injury in rats By DANG Shuang-suo, ZHANG Xin, JIA Xiao-li, CHENG Yan-an, SONG Ping, LIU En-qi, HE Qian and LI Zong-fang

[7] Effects of dietary Astragalus polysaccharides on growth performance and immune function in weaned pigs by S.L. Yuan, X.S. Piao, D.F. Li, S.W. Kim, H.S. Lee and P.F. Guo

[8] Analysis of the relationship between HBsAg and serological markers of chronic hepatitis B and establishment of HBsAg-deficient hepatitis B mouse model by Yi Z. CNKI:CDMD:2.1018.039903

[9] China Medical Association infectious branch. The standard of grading and staging of viral hepatitis. Zhonghua Chuanranbing Zazhi 1995; 13: 241-247

Downloads

Published

2023-06-01