Methionine restriction improve insulin resistance by reducingmitochondria oxidative stress
DOI:
https://doi.org/10.61173/ptehpa84Keywords:
insulin, Skeletal muscle, testAbstract
Type 2 diabetes is a chronic metabolic disorder whose prevalence has been increasing steadily worldwide and is closely
linked to the epidemic of obesity. The most common features of Type 2 Diabetes are hyperglycemia, insulin resistance,
and relative insulin deficiency. Insulin resistance refers to incorrect responses to insulin among cells whose physiology
depends on insulin, such as adipocytes and cardiomyocytes. Methionine is an essential amino acid, so it must be
consumed in the diet to avoid neurological impairment and visual symptoms caused by methionine deficiency. This
provides a potential explanation that methionine restriction can alleviate insulin resistance by regulating mTORC1. This
study aims to investigate the effect of methionine restriction on insulin resistance and mitochondria oxidative stress.
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