Whether Carotenoids and Quercetin Affect the Proliferation andExpression of PPARγ Protein in Leukemia K562 Cells
DOI:
https://doi.org/10.61173/58mg8711Keywords:
carotenoids, PPARγ protein, K56 cellsAbstract
Carotenoids are some of the most abundant pigments in nature, ranging from yellow to red. Carotenoids can divide into
two categories: carotenoids composed of hydrocarbon elements and lutein-containing oxygen elements. They are lipidsoluble pigments, and some contain carbonyl or enol groups, which are water-soluble. Carotenoids absorb visible light
from 400 nm to 600 nm, while special ones such as octa-hydro lycopene and hexahydrolycopene only absorb ultraviolet
light. Quercetin is a flavonoid compound widely found in fruits and vegetables. Its chemical structure phenolic hydroxyl
group is the basis of antioxidant action, which can be used for hydrogen to quench oxygen free radicals. It is oxidized
to form a highly stable catechol structure. It has a variety of biological activities and pharmacological effects, such as
expanding coronary blood vessels and inhibiting tumor cell proliferation. This paper shows that the K562 cell growth
rate in carotenoids and quercetin treatment groups was slower than the control group.
References
[1] Ke Hu and Na Li, Carotenoids, the much-loved antioxidant family, University of chemical, 2010
[2] Verschoyle RD, Steward WP, Gescher AJ. Putative cancer chemo preventive agents of dietary origin-how safe are they?. Nutr Cancer. 2007, 59 (2):152–62.
[3] Rietjens IM, Boersma MG, van der Woude H, Jeurissen SM, Schutte ME, Alink GM. Flavonoids and alkenyl benzenes: mechanisms of mutagenic action and carcinogenic risk. Mutat. Res. July 2005, 574 (1–2): 124–38.
[4] van der Woude H, Alink GM, van Rossum BE; et al. Formation of transient covalent protein and DNA adducts by quercetin in cells with and without oxidative enzyme activity. Chem. Res. Texico. December 2005, 18 (12): 1907–16.
[5] Neu Houser ML. Dietary flavonoids and cancer risk: evidence from human population studies. Nutr Cancer. 2004, 50 (1): 1–7.
[6] Murakami A, Ashida H, Terao J. Multitargeted cancer prevention by quercetin. Cancer Lett. October 2008, 269 (2): 315–25.
[7] Nöthlings U; et al. Flavanols and pancreatic cancer risk. American Journal of Epidemiology. 2007, 166 (8): 924–931.
[8] JS Bonifacio, M Dassault, JB Hartford, et al. Experimental Guidelines for cell biology. Beijing: Science Press,2007: 370.39.
[9] Benzie IFF, Strain J. The ferric reducing ability of plasma(FRAP) as a measure of “antioxidant power” the FRAP assay. Analytical Biochemistry,1996, 239(3): 70-76.
[10] Garland M, Willett WC, Manson JE, et al. Antioxidant micronutrients and breast cancer[J].J Am Coll Nutr,1993,12(4):400-411.
[11] Farrow B, Connor KL, Hashimoto K, et al. selective activation of PPAR gamma inhibits pancreatic invasion and decreases expression of tissue plasminogen activator[J]. Surger,2003,134(2):206-212.
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