Recent progress in the study of chemical constituents and pharmacological effects of Cassia Semen
DOI:
https://doi.org/10.61173/5tkc0f55Keywords:
Cassia Semen, Chemical composition, Pharmacological effectsAbstract
Cassia Semen is the mature seed of the leguminous plant Cassia obtusifolia L. or Cassia tora L. They are known for clearing heat, improving vision, and promoting bowel movements. Modern chemical research has shown that Cassia Semen is rich in anthraquinones, naphthopyranones, and fatty acids, among other chemical components. Pharmacological studies have demonstrated various effects of Cassia Semen, including lowering blood lipid levels, reducing blood pressure, regulating blood glucose, promoting bowel movements, protecting the liver, improving vision, exhibiting antioxidant and anti-aging properties, inhibiting bacteria, and exerting anti-cancer effects. By reviewing recent domestic and international modern research on Cassia Semen, this article provides a literature review on its chemical constituents, pharmacological effects, and recent progress in clinical studies. The aim is to offer references for the rational clinical application of Cassia Semen, the mechanisms of its pharmacological and toxicological effects, as well as the modern development of traditional Chinese medicine.
References
[1] National Pharmacopoeia Committee. Pharmacopoeia of the People’s Republic of China [S]. 1. Beijing: China Medical Science and Technology Press,2020:151.
[2] Li Qiuhong. Research Progress on chemistry, pharmacology, and processing of Cassia seed [J]. Chinese Journal of Traditional Chinese Medicine,2006,34(6):49-50.
[3] Hao Yan-Jun, Sang Yu-Li, Zhao Yu-Qing, et al. Study on the chemical constituents of anthraquinones in Cassia seed [J]. Chinese Herbal Medicine, 2003, 34 (1): 18-19.
[4] Liu Bin, GONG Hongxia, Xiao Xuefeng, et al. Research progress on Cassia seed’s chemical constituents and pharmacological effects [J]. Drug Evaluation Research, 2010,33 (4);312-313.
[5] Meng Zhe, Wang Manze, Liu Wanyi. Cassia seed of unsaturated fatty acids of high-performance liquid chromatography (HPLC) overlapping peak resolution [J]. Chemical world, 2012 does (03) : 146-150. The DOI: 10.19500 / j.carol carroll nki. 0367-6358.2012.03.006.
[6] Xiang Lue, HU TUS, GU Qing-Qing, et al. Determination of fatty oil composition and stability of Cassia seed by GC-MS [J]. Shanghai Journal of Traditional Chinese Medicine, 2012,46 (7) : 78-81.
[7] Zhang J W. Study on structure of Cassia polysaccharide and its effects on growth, immunity and intestinal microecology of piglets [D]. Nanchang University,2005.
[8] Kingleith, Weng Kingmoon. Research and development progress of Cassia seed [J]. Straits Pharmacy,2012,24(03):42-44.
[9] Zhang B, Xie Yunliang. Protective effect of total anthraquinone of Cassia seed on immune liver injury in mice [J]. Journal of Beihua University (Natural Science Edition),2018,19(06):741-744.
[10] PU J W,YANG x,WU Y,et al. Protective effect of total an-thraquinone in semen cassia on acute liver injuy induced by LPSin rats and its mechanism[ J ]. China J Mod Med,2020,30(20) :6-11.
[11] Wan M. Comparative study on the content determination of various components of Cassia seed and its protective effect on liver [D]. Liaoning University of Chinese Medicine,2019.
[12] Zhu Zhou-Liang, ZHANG Shi-Xin, ZHENG Yun-Yan et al. Cassia seed extract on the effects of hyperlipidemia rats blood lipid and liver and kidney function [J]. Journal of Preventive Medicine, 2021 (12) : 1290-1294. The DOI: 10.19485 / j.carol carroll nki issn2096-5087.2021.12.025.
[13] Li Yujing, Hou Wei, Chen Wenhui et al. Effect of anthraquinone glycoside of cassia seed on the expression of fatty acid β-oxidation-related enzyme protein in rats with nonalcoholic fatty liver disease [J]. Western Chinese Medicine, 2021,34(01):6-10.
[14] Guo Huan, Li Fengqing, Yang Changlin et al. Cassia seed water decoction reduced nutritional hyperlipemia rats blood lipid concentration-response relationship study [J]. Journal of traditional Chinese medicine pharmacology and clinical, 2017 (5) : 94-98. The DOI: 10.13412 / j.carol carroll nki zyyl. 2017.05.025.
[15] Li Yanwen, Wang Ting, Xu Lanlan et al. Regulation mechanism of RAAS system by water extract of Cassia seed in hypertensive rats [J]. Journal of Veterinary Medicine,2019,35(08):774-776.
[16] Ye Quanying, Chen Qisheng, Li Yanwen et al. Changes of blood pressure induced by N-nitro-L-arginine methyl ester induced by water extract of cassia seed in hypertensive model rats [J]. Journal of Tissue Engineering, 2019,25(11):1705-1711.
[17] Tang Z H. Study on the therapeutic mechanism of cassia seed for dry eye based on network pharmacology and molecular docking [J]. Shandong chemical industry, 2023,52 (05) : 43- 49. DOI: 10.19319 / j.carol carroll nki. Issn 1008-021 - x. 2023.05.051.
[18] He Yu, Yang De, Yan Hong. Effect of Sirt1/PPARγ pathway regulated by total anthraquinone of cassia seed on H2O2-induced oxidative damage of human lens epithelial cells [J]. Chinese journal of ophthalmology of traditional Chinese medicine, 2022, 32 (02) : 94-99 + 106. DOI: 10.13444 / j.carol carroll nki zgzyykzz. 2022.02.003.
[19] Li Lei, ZHAO Huajin, Wu Zitao, et al. Network pharmacological analysis of antioxidant mechanism of Cassia Dean&Francis seed [J]. Acta Agriculturae Zhejiangensis, 2019, 32 (10) : 1855- 1865.
[20] Lin Shuihua, Huang Youxia, Huang Xiaoyi et al. Different semen cassiae processed products of anthraquinone compounds content and antioxidant activity comparison [J]. Journal of fujian province traditional Chinese medicine, 2019, 50 (02) : 41 and 42 + 50, DOI: 10.13260 / j.carol carroll nki JFJTCM. 011800.
[21] CAI Juntai, Xu Zhiyin, Xu Guoqiang, et al. Antioxidant activity of proteolytic products of cassia seed: thermal and gastrointestinal stability, peptide identification and computer analysis [J]. Modern Food Science and Technology, 2019,35 (9) : 38-48.
[22] Long Yuan-Chun, Zhang Xin, Wan Guo-Dong, et al. Determination of anthraquinone compounds and antioxidant activity of Cassia seeds from different habitats [J]. Food Science, 2017,38 (16) : 145-151.
[23] Li X F. Study on antioxidant activity of Cassia seed and orange peel flavonoid complex [J]. Journal of Tianshui Normal University,2017,37(02):29-31.
[24] Nawabjohn MS, Sivaprakasam P, Anandasadagopan SK, etal. Green Synthesis and Characterisation of Silver Nanoparticles Using Cassia tora Seed Extract and Investi-gation of Antibacterial Potential. Appl Biochem Biotechnol,2022,194(1 ):464—478
[25] Dong Yujie, Jiang Yuanqi, Liu Yi et al. Prediction analysis of chemical constituents, pharmacological effects and quality markers of Cassia seed [J]. Chinese Herbal Medicine,2021,52(09):2719-2732.
[26] Li Fengqing, Guo Huan, Liu Fei et al. Comparative study on contents of anthraquinones in the seeds of Cassia [J]. Asianpacific Traditional Medicine,2018,14(05):48-51.
[27] Wu Suhui, Wang Linlin, Li Hanbing, et al. Effect of Cassia seed on overall energy characteristics of Bombyx mori [J]. Pharmacology and Clinic of Chinese Materia Medica, 2016,32 (3) : 92-95.
[28] Gao Wa, FU Libo. Effects of Cassia seed on small intestinal smooth muscle activity in isolated rabbits [J]. Chinese Journal of Gerontology,2015,35(03):735-736.
[29] Song Yunmei. Protective effect of anthraquinone glycoside of Cassia seed on renal injury in diabetic rats [J]. Clinical Research of Chinese Medicine,2018,10(20):6-7.
[30] Wang X. Study on pharmacology and toxicology of cassia seed based on transmembrane transporter in mercuryinduced nephrotoxicity and cholestatic liver injury [D]. Tianjin university, 2018. DOI: 10.27356 /, dc nki. Gtjdu. 2018.000243.
[31] Chen Jianshuang, Wang Yifan, Li Shasha et al. Protective effect of anthraquinone glycoside of cassia seed on renal injury in two kidneys and one clamp hypertensive rats [J]. Chinese Journal of Geriatrics,2017,37(19):4752-4753.
[32] Wang Qiu-Yan. Study on preparation technology, quality control and anti-diabetic effect of extract of Cassia seed [D]. Huazhong university of science and technology, 2019. DOI: 10.27157 /, dc nki. Ghzku. 2019.004433.
[33] Ko E, Um MY, Choi M, et al. Cassia tora Seed Improves Pancreatic Mitochondrial Function Leading to Recovery of Glucose Metabolism. Am J Chin Med,2020,48(3 ):615—629.
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