Potential Application of Dietary Fiber in Improving Diabetes and Insulin Resistance
DOI:
https://doi.org/10.61173/75mqkb09Keywords:
Dietary fiber, Diabetes, Insulin resistance, Short chain fatty acidsAbstract
The relationship between dietary fiber, short chain fatty acid (SCFA) and diabetes has been confirmed by some current studies. This article examined the influence of dietary fiber, a necessary type of fiber for the human body, on human Type 2 Diabetes Mellitus (T2DM), and how to manage the advancement of T2DM by converting it into SCFA by fermentation. This article introduces the fundamental connection between T2DM, dietary fiber and SCFA. It discusses the relationship between dietary fiber and body weight from various perspectives, as well as how the risk of obesity and T2DM is reduced by dietary fiber, manages insulin resistance, and enhances gastrointestinal flora. Adequate consumption of dietary fiber can help manage metabolic illnesses including obesity and T2DM, and SCFA play an important role in this process. This paper aims to clarify the relationship between T2DM and dietary fiber and SCFA, and inspire people to think about non-drug treatment methods for T2DM.
References
[1] Abdul Basith Khan M, Hashim M J, King J K, et al. Dean&Francis Epidemiology of Type 2 Diabetes - Global Burden of Disease and Forecasted Trends, Journal of Epidemiology and Global Health, 2020, 10(1): 107-111
[2] Lee S H, Park S Y, Choi C S. Insulin resistance: from mechanisms to therapeutic strategies. Diabetes & metabolism journal, 2022, 46(1): 15.
[3] Anderson J W, Baird P, Davis Jr R H, et al. Health benefits of dietary fiber. Nutrition reviews, 2009, 67(4): 188-205.
[4] Simpson H L, Campbell B J. dietary fibre-microbiota interactions. Alimentary pharmacology & therapeutics, 2015, 42(2): 158-179.
[5] animal, and vegetable protein and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL study. Diabetes care, 2010, 33(1): 43-48.
[6] Virtanen H E K, Koskinen T T, Voutilainen S, et al. Intake of different dietary proteins and risk of type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. British journal of nutrition, 2017, 117(6): 882-893.
[7] Weickert M O, Roden M, Isken F, et al. Effects of supplemented isoenergetic diets differing in cereal fiber and protein content on insulin sensitivity in overweight humans. The American journal of clinical nutrition, 2011, 94(2): 459-471.
[8] infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial. Scientific reports, 2017, 7(1): 2360.
[9] Liljeberg H, Björck I. Delayed gastric emptying rate may explain improved glycaemia in healthy subjects to a starchy meal with added vinegar. European journal of clinical nutrition, 1998, 52(5): 368-371.
[10] Leeman M, Östman E, Björck I. Vinegar dressing and cold storage of potatoes lowers postprandial glycaemic and insulinaemic responses in healthy subjects. European journal of clinical nutrition, 2005, 59(11): 1266-1271.
[11] Hu F B, Van Dam R M, Liu S. Diet and risk of type II diabetes: the role of types of fat and carbohydrate. Diabetologia, 2001, 44: 805-817.
[12] Riccardi G, Rivellese A A. Effects of dietary fiber and carbohydrate on glucose and lipoprotein metabolism in diabetic patients. Diabetes care, 1991, 14(12): 1115-1125.
[13] Myhrstad M C W, Tunsjø H, Charnock C, et al. Dietary fiber, gut microbiota, and metabolic regulation—Current status in human randomized trials. Nutrients, 2020, 12(3): 859.
[14] Malone J I, Hansen B C. Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?. Pediatric diabetes, 2019, 20(1): 5-9.
[15] Den Besten G, Bleeker A, Gerding A, et al. Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγdependent switch from lipogenesis to fat oxidation. Diabetes, 2015, 64(7): 2398-2408.
[16] Lu YuanYuan L Y Y, Fan ChaoNan F C N, Li Ping L P, et al. Short chain fatty acids prevent high-fat-diet-induced obesity in mice by regulating G protein-coupled receptors and gut microbiota. Scientific Reports, 2016, 6(1):37589.
[17] Kondo T, Kishi M, Fushimi T, et al. Acetic acid upregulates the expression of genes for fatty acid oxidation enzymes in liver to suppress body fat accumulation. Journal of agricultural and food chemistry, 2009, 57(13): 5982-5986.
[18] González Hernández M A, Canfora E E, Jocken J W E, et al. The short-chain fatty acid acetate in body weight control and insulin sensitivity. Nutrients, 2019, 11(8): 1943.
[19] Gilbert J A, Blaser M J, Caporaso J G, et al. Current understanding of the human microbiome. Nature medicine, 2018, 24(4): 392-400.
[20] Ley R E, Turnbaugh P J, Klein S, et al. Human gut microbes associated with obesity. nature, 2006, 444(7122): 1022-1023.
[21] Canfora E E, Jocken J W, Blaak E E. Short-chain fatty acids in control of body weight and insulin sensitivity. Nature Reviews Endocrinology, 2015, 11(10): 577-591.
[22] Myhrstad M C W, Tunsjø H, Charnock C, et al. Dietary fiber, gut microbiota, and metabolic regulation—Current status in human randomized trials. Nutrients, 2020, 12(3): 859.
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