The Application and Research Progress of Hydrogel Loading Stem Cells in Bone Regeneration

Authors

  • Shenyu Zhao

DOI:

https://doi.org/10.61173/g7cn0709

Keywords:

Bone regeneration, hydrogel, stem cells, mesenchymal stem cells

Abstract

Nowadays, osteogenesis technology is one of the hot topics in the current orthopedic field. Globally, improving the stability and efficiency of bone regeneration has become a problem that society has been studying. Due to its good tunability, compatibility, and combination ability, hydrogel is gradually applied to bone regeneration technology. Stem cells can differentiate and copy, and have certain clinical potential in the regeneration and treatment of bone tissue. In recent years, many new types of hydrogel materials have been developed, and some are expected to be applied to clinical trials. Likewise, stem cell therapy is also at the forefront of medical research today. Many types and good characteristics make part of them smoothly applied to bone regeneration. In this review, the experimental data and research results of cutting-edge and developmental hydrogel-loading stem cell technology in the field of bone regeneration are collected, and the development and application of this technology will be summarized. The article contains the nature, preparation, and development of hydrogel; discusses the effective role of hydrogel and stem cells in the field of bone regeneration; combined with biological factor therapy and the future development of new technologies. The article also focuses on the development and application of different types of new composite hydrogel. At the same time, these hydrogels make bone regeneration technology more efficient and stable through stem cells with different characteristics. Therefore, this review tells the far-reaching impact of this technology on the future of bone regeneration technology, skeletal development, and even organizational repair.

References

[1] Naghmeh A, Stephen H, Robert M, et al. Porous scaffolds for bone regeneration. Journal of Science: Advanced Materials and Devices, 2020, 5(1): 1-9.

[2] Wei W, Ma Y, Yao X, et al. Advanced hydrogels for the repair of cartilage defects and regeneration. Bioact Mater, 2020, 6(4): 998-1011.

[3] Ishita M, Gurvinder K, Amir S, et al. Progress in 3D bioprinting technology for tissue/organ regenerative engineering. Biomaterials, 2020, 226: 119536.

[4] Zhang P, Qi J, Zhang R, et al. Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects. Biomaterial Science, 2024, 12: 308- Dean&Francis 329.

[5] Gauvin R, Parenteau-Bareil R, Dokmeci MR, et al. Hydrogels and microtechnologies for engineering the cellular microenvironment. WIREs Nanomed Nanobiotechnol, 2012, 4: 235-246.

[6] Enas M. Ahmed. Hydrogel: Preparation, characterization, and applications: A review. Journal of Advanced Research, 2015, 6(2): 105-121.

[7] Liu Cheng, Xu Na, Zong Qida, et al. Hydrogel prepared by 3D printing technology and its applications in the medical field. Colloid and Interface Science Communications, 2021, 44: 100498.

[8] Ju Yikun, Hu Yue, Yang Pu, et al. Extracellular vesicle-loaded hydrogels for tissue repair and regeneration. Materials Today Bio, 2023, 18: 100522.

[9] Ashwani PV, Gopika G, Arun KV, et al. Stimuli-Responsive and Multifunctional Nanogels in Drug Delivery. Chem Biodivers, 2023, 20(11): e202301009.

[10] Feng Naibo, Chang Fei, Han Yu, et al. Biopolymer materials for cartilage tissue engineering. Chinese Journal of Tissue Engineering Research, 2018, 22(26): 4215-4221.

[11] Yuan X, Ding L, Deng D. Research progress of hydrogel combined with mesenchymal stem cells in the treatment of spinal cord injury. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2021, 38(4): 805-811.

[12] Tu Yujie, Chen Nuan, Li Chuping, et al. Advances in injectable self-healing biomedical hydrogels. Acta Biomaterialia, 2019, 90: 1-20.

[13] Zakrzewski W, Dobrzyński M, Szymonowicz M, et al. Stem cells: past, present, and future. Stem Cell Res Ther, 2019, 10(1): 68.

[14] Lucie B, Jana Z, Martina T, et al. Stem cells: their source, potency and use in regenerative therapies with focus on adiposederived stem cells – a review. Biotechnology Advances, 2018, 36(4): 1111-1126.

[15] Zhao T, Wei Z, Zhu W, et al. Recent Developments and Current Applications of Hydrogels in Osteoarthritis. Bioengineering (Basel), 2022, 9(4): 132.

[16] Debnath T, Ghosh S, Potlapuvu US, et al. Proliferation and differentiation potential of human adipose-derived stem cells grown on chitosan hydrogel. PLoS One, 2015, 10(3): e0120803.

[17] Calis M, Irmak G, Demirtaş TT, et al. Photobiomodulation combined with adipose-derived stem cells encapsulated in methacrylated gelatin hydrogels enhances in vivo bone regeneration. Lasers Med Sci, 2022, 37(1): 595-606.

[18] Ji X, Yuan X, Ma L, et al. Mesenchymal stem cell-loaded thermosensitive hydroxypropyl chitin hydrogel combined with a three-dimensional-printed poly(ε-caprolactone) /nanohydroxyapatite scaffold to repair bone defects via osteogenesis, angiogenesis and immunomodulation. Theranostics, 2020,10(2): 725-740.

[19] Sajad-Daneshi S, Tayebi L, Talaei-Khozani T, et al. Reconstructing Critical-Sized Mandibular Defects in a Rabbit Model: Enhancing Angiogenesis and Facilitating Bone Regeneration via a Cell-Loaded 3D-Printed Hydrogel-Ceramic Scaffold Application. ACS Biomater Sci Eng, 2024 (prepublish).

[20] Bai L, Tao G, Feng M, et al. Hydrogel Drug Delivery Systems for Bone Regeneration. Pharmaceutics, 2023, 15(5): 1334.

Downloads

Published

2024-06-06