The Mechanism and Clinical Research Progress of Tcm Treatment of Breast Cancer
DOI:
https://doi.org/10.61173/kkk80w98Keywords:
Traditional Chinese medicine, Breast cancer, Mechanism, Research progressAbstract
Breast cancer, a prevalent malignant tumor, exhibits intricate pathogenesis and rapid disease advancement. Recent analyses of both national and global scientific literature reveal the efficacy of traditional Chinese medicine (TCM) monomers or formulations in modulating biological processes. These interventions target genes and signaling pathways, leading to the inhibition of breast cancer cell proliferation, induction of apoptosis, and modulation of cancer cell resistance to chemotherapy and endocrine therapy. Moreover, emerging clinical investigations indicate the effectiveness of TCM formulations, acupuncture in conjunction with TCM, or integrative TCM and Western medicine regimens in treating breast cancer patients. These findings not only offer preliminary evidence of TCM’s potential efficacy and benefits in improving treatment outcomes and reducing toxicity in tumor diseases but also address existing limitations in Western medicine approaches to breast cancer treatment. Consequently, it is advisable to collaboratively establish a distinctive diagnostic and therapeutic framework that integrates TCM and Western medicine. Such an approach aims to diminish recurrence and mortality rates among breast cancer patients, enhance patient survival outcomes, and facilitate pertinent clinical endeavors.
References
[1] Bulte, C.A., K.M. Hoegler, and A. Khachemoune, Collision tumors: A review of their types, pathogenesis, and diagnostic challenges. Dermatologic Therapy, 2020. 33(6): p. e14236.
[2] Cullen, J.M. and M. Breen, An overview of molecular cancer pathogenesis, prognosis, and diagnosis. Tumors in domestic animals, 2016: p. 1-26.
[3] Falanga, A. and M. Benedetta Donati, Pathogenesis of thrombosis in patients with malignancy. International journal of hematology, 2001. 73: p. 137-144.
[4] Acevedo, N., Epigenetic mechanisms of asthma and allergy. 2015: Karolinska Institutet (Sweden).
[5] Ilango, S., et al., Epigenetic alterations in cancer. Frontiers in Bioscience-Landmark, 2020. 25(6): p. 1058-1109.
[6] Blake, G.E.T., Investigating the Epigenetic Mechanism Behind Transgenerational Inheritance in Mice with Abnormal Folate Metabolism. 2019.
[7] Arneth, B., Tumor microenvironment. Medicina, 2019. 56(1): p. 15.
[8] Whiteside, T., The tumor microenvironment and its role in promoting tumor growth. Oncogene, 2008. 27(45): p. 5904- 5912.
[9] Spano, D. and M. Zollo, Tumor microenvironment: a main actor in the metastasis process. Clinical & experimental metastasis, 2012. 29(4): p. 381-395.
[10] Zhang, L., et al., Immune landscape of colorectal cancer tumor microenvironment from different primary tumor location. Frontiers in immunology, 2018. 9: p. 1578.
[11] Yuan, Y., et al., Role of the tumor microenvironment in tumor progression and the clinical applications. Oncology reports, 2016. 35(5): p. 2499-2515.
[12] Arif, A.A., The role of the microenvironment and inflammation in the promotion of cancer metastasis. 2018, University of British Columbia.
[13] Paupert, J., et al., Tumor angiogenesis and lymphangiogenesis: microenvironmental soil for tumor progression and metastatic dissemination. Molecular Mechanisms of Angiogenesis: From Ontogenesis to Oncogenesis, 2014: p. 283-306.
[14] Prehn, R.T., A clonal selection theory of chemical carcinogenesis. Journal of the National Cancer Institute, 1964. 32(1): p. 1-17.
[15] Gonzalez, M.J., et al., The bio-energetic theory of carcinogenesis. Medical hypotheses, 2012. 79(4): p. 433-439.
[16] Devi, P.U., Basics of carcinogenesis. Health Adm, 2004. 17(1): p. 16-24.
[17] Kaiser, R.H., et al., Large-scale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity. JAMA psychiatry, 2015. 72(6): p. 603- 611.
[18] Morales-Muñoz, I., et al., Longitudinal Associations Between Cognitive Deficits in Childhood and Psychopathological Symptoms in Adolescence and Young Adulthood. JAMA Network Open, 2021. 4(4): p. e214724-e214724.
[19] Thompson, P.M., et al., Structural MRI and brain development. International review of neurobiology, 2005. 67: p. 285-323.
[20] Tandon, P.S., et al., Socioeconomic inequities in youth participation in physical activity and sports. International Journal of Environmental Research and Public Health, 2021. 18(13): p. 6946.
[21] Caspi, A., et al., Longitudinal assessment of mental health disorders and comorbidities across 4 decades among participants in the Dunedin birth cohort study. JAMA network open, 2020. 3(4): p. e203221-e203221.
[22] Huang, C. and G. Hu, Shikonin suppresses proliferation and induces apoptosis in endometrioid endometrial cancer cells via modulating miR-106b/PTEN/AKT/mTOR signaling pathway. Bioscience Reports, 2018. 38(2): p. BSR20171546.
[23] Laurent, J.S., et al., Associations among body mass index, cortical thickness, and executive function in children. JAMA pediatrics, 2020. 174(2): p. 170-177. Dean&Francis
[24] Chang, H. and Z. Zou, Targeting autophagy to overcome drug resistance: further developments. Journal of hematology & oncology, 2020. 13(1): p. 159.
[25] Uhlhaas, P.J., P.D. McGorry, and S.J. Wood, Toward a paradigm for youth mental health. JAMA psychiatry, 2021. 78(5): p. 473-474.
[26] Townsend, J.D., et al., Frontostriatal neuroimaging findings differ in patients with bipolar disorder who have or do not have ADHD comorbidity. Journal of affective disorders, 2013. 147(1- 3): p. 389-396.
[27] Bos, M.G., et al., Longitudinal structural brain development and externalizing behavior in adolescence. Journal of Child Psychology and Psychiatry, 2018. 59(10): p. 1061-1072.
[28] Shanker, A. and F.M. Marincola, Cooperativity of adaptive and innate immunity: implications for cancer therapy. Cancer Immunology, Immunotherapy, 2011. 60: p. 1061-1074.
[29] Cao, Z., et al., Fuzheng Yiliu Granule inhibits the growth of hepatocellular cancer by regulating immune function and inducing apoptosis in vivo and in vitro. Chinese journal of integrative medicine, 2011. 17(9): p. 691-697.
[30] Zhao, X., et al., Saikosaponin A inhibits breast cancer by regulating Th1/Th2 balance. Frontiers in pharmacology, 2019. 10: p. 624.
[31] Kim, S.H., et al., Anti-cancer activity of Angelica gigas by increasing immune response and stimulating natural killer and natural killer T cells. BMC complementary and alternative medicine, 2018. 18: p. 1-13.
[32] Ricci, G., et al., Astrocyte–neuron interactions in neurological disorders. Journal of biological physics, 2009. 35(4): p. 317-336.
[33] Grover, V.P., et al., Magnetic resonance imaging: principles and techniques: lessons for clinicians. Journal of clinical and experimental hepatology, 2015. 5(3): p. 246-255.
[34] Caron, C. and M. Rutter, Comorbidity in child psychopathology: Concepts, issues and research strategies. Journal of child Psychology and Psychiatry, 1991. 32(7): p. 1063-1080.
[35] Warren, W., Journal of Child Psychology and Psychiatry and Allied Disciplines. Joint Editors: CB Hindley, Elizabeth Irvine and Emanuel Miller. Volume 1, No. 1, 01, 1960. Pergamon Press, Oxford. Journal of Mental Science, 1960. 106(445): p. 1594-1594.
[36] Mahmood, S.S., et al., The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective. The lancet, 2014. 383(9921): p. 999-1008.
[37] Yokokura, M., et al., In vivo imaging of dopamine D1 receptor and activated microglia in attention-deficit/hyperactivity disorder: a positron emission tomography study. Molecular Psychiatry, 2020: p. 1-10.
[38] McIntosh, K., S.V. Ty, and L.D. Miller, Effects of schoolwide positive behavioral interventions and supports on internalizing problems: Current evidence and future directions. Journal of Positive Behavior Interventions, 2014. 16(4): p. 209- 218.
[39] Achenbach, T.M., et al., Internalizing/externalizing problems: Review and recommendations for clinical and research applications. Journal of the American Academy of Child & Adolescent Psychiatry, 2016. 55(8): p. 647-656.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 by the authors.

This work is licensed under a Creative Commons Attribution 4.0 International License.
