The Effect Of Ellagic Acid On Anti-Aging
DOI:
https://doi.org/10.61173/8nysn657Keywords:
Ellagic acid, Urolithin, Anti-aging, Biological pathwayAbstract
Aging includes a variety of phenotypes, which are determined by a variety of complex mechanisms, with cell aging and mitochondrial dysfunction as the main influencing factors. Ellagic acid is a natural compound with strong biological activity, which can delay aging by resisting oxidation, eliminating inflammation, repairing mitochondrial in the body, inhibit oxidative stress, and eliminate cell aging caused by oxidation, the elimination of mitochondrial dysfunction and other molecular pathways. Its ability to resist oxidation is mainly reflected in the strong free radical scavenging ability of ellagic acid, which can reduce the level of high-level ROS is mainly reflected in ellagic acid’s potential to reduce the level of inflammation-related factors, participate in the regulation of inflammatory signaling pathways, and thus reduce the level of inflammation in the body; the repair of mitochondrial dysfunction is mainly reflected in the potential of ellagic acid with regards to participate in the activation of mitochondrial autophagy, improve mitochondrial quality, enhance respiratory capacity, and delay cell aging. This article delves into the origins and metabolic routes of ellagic acid, exploring the intricate biological mechanisms underlying its anti-aging properties, and analyzes the related application value and research fields of ellagic acid.
References
This paper summarized the research progress of anti-ag- of aging. Cell, 2013, 153(6): 1194-1217. ing effects of EA, including the source, metabolism, [2]Song MJ, Park CH, Kim H, et al. Carnitine acetyltransferase anti-aging effects, related mechanisms and application deficiency mediates mitochondrial dysfunction-induced prospects of EA. Firstly, EA is naturally present in a wide cellular senescence in dermal fibroblasts. Aging Cell, 2023, array of berries and nuts, taking the shape of a condensed 22(11):e14000. compound. Upon undergoing metabolic transformation by [3]Deng Xunkun, Zhang Tiantian, Liu Jing, et al. Ellagic acid the intestinal flora, it transforms into urolithin, conferring affects TGF-β-induced EMT in AML-12 cells by regulating Nrf2 numerous salutary benefits to human physiology. These and NLRP3 pathways. J. S.-Cent. Univ. Natl. (Nat. Sci. Ed.),
benefits encompass antioxidative, anti-inflammatory, and 2023, 42(6): 745-751. anti-aging properties, among various other positive out- [4]Ríos JL, Giner RM, Marín M, et al. A Pharmacological
comes on bodily functions. EA can achieve the purpose of Update of Ellagic Acid, Planta Medica, 2018, 84(15): 1068- anti-aging by activating mitochondrial autophagy, improv- 1093. ing mitochondrial levels and repairing their dysfunction. [5]Zhang Mengwei, Cui Shumao, Mao Bingyong, et al. Ellagic EA can also act on oxidation and inflammation, which are acid and intestinal microflora metabolite urolithin A: A review closely related to aging. The antioxidant effect of EA has on its sources, metabolic distribution, health benefits, and been systematically verified by various experiments in biotransformation. Critical reviews in food science and nutrition,
vivo and in vitro. It achieves antioxidant effects through 2023,63(24): 6900-6922. strong free radical scavenging ability. It has the ability [6]Ohtani N, Mann DJ, Hara E. Cellular senescence: Its role in
to eliminate harmful radicals and oxygen species that tumor suppression and aging. Cancer Science, 2010, 100(5):792- are reactive in the body, thus reducing oxidative stress. 797. Although the exact anti-inflammatory mechanism of EA [7]Godhamgaonkar AA, Sundrani DP, Joshi SR. Role of remains unclear, it is well-established that ellagic acid has maternal nutrition and oxidative stress in placental telomere the capacity to lower the concentration of inflammatory attrition in women with preeclampsia. Hypertension in
factors and participate in the regulation of inflammatory Pregnancy, 2021, 40(1): 63-74. pathways in the body, which is enough to show that it has [8]Pellerin L, Bouzier-Sore AK, Agnès Aubert, et al. Activitycertain anti-inflammatory effects. In addition, EA can also dependent regulation of energy metabolism by astrocytes: An
act on skeletal muscle and skin to fight aging. The investi- update. Glia, 2007, 55(12): 1251-1262. gation into the anti-aging mechanism of ellagic acid offers [9]Li Hongyan, MAO Angiong, LiU Ting, et al. Effect and valuable insights into the aging process, establishing a sci- mechanism of chronic oxidative stress induced by hydrogen entific framework for the development of innovative an- peroxide on microglialceluar senescence. West China Medical
ti-aging techniques. This, in turn, aims to enhance human Journal, 2023, 38(8): 1188-1194. quality of life and address health issues associated with [10]Zhang Bing, Yan Pengyi, Li Zixuan, et al. LARP7 aging. ameliorates cellular senescence and aging by allosterically
The study of EA should not be limited to the field of enhancing SIRT1 deacetylase activity. Cell Reports, 2023, 37(8): health, but should be expanded to other fields. Its anti- 110038. oxidant and anti-aging properties can also be applied to [11]RODIER F, COPPE JP, PATIL C K, et al. Persistent DNA the food industry as food preservatives and fresheners. In damage signalling triggers senescence-associated inflammatory
addition, it may be possible to link EA with the current cytokine secretion. Nature Cell Biology, 2009, 11(8): 973-979. hot research on cancer drugs, explore the value of EA in [12]Huang Yaqun, Ge Ming-Xia, Li Yu-Hong, et al. Longevitythe field of medicine, and develop corresponding drugs or Associated Transcription Factor ATF7 Promotes Healthspan by health care products. Although the research direction and Suppressing Cellular Senescence and Systematic Inflammation.
application prospect of EA are very extensive, its devel- Aging and Disease, 2023, 14(4): 1374-1389. opment and application still face some problems, such as [13]Zhang Guo, Li Juxue, Purkayastha Sudarshana, et al. Hypothalamic programming of systemic ageing involving IKK- Dean&Francis
beta, NF-kappaB and GnRH. Nature, 2013, 497(7448): 211-216. [21]Zheng YZ, Fu ZM, Deng G, et al. Free radical scavenging [14]Bala I, Bhardwaj V, Hariharan S, et al. Analytical methods potency of ellagic acid and its derivatives in multiple H+/e‒
for assay of ellagic acid and its solubility studies. J Pharm processes. Phytochemistry, 2020, 180: 112517.
Biomed Anal, 2006, 40(1): 206-210. [22]MA Mingbiao, DU Tingyi, TAO Lüyan, et al. Research [15]Tang Wanpei . Analysis of intestinal flora of different advances of Hippo signaling pathway in inflammation. Current
metabolites of ellagic acid and its metabolic characteristics. Pharmaceutical Design, 2020, 36(6): 752-758.
Hainan University, 2021. [23]Masamune A, Satoh M, Kikuta K, et al. Ellagic acid [16]Iglesias-Aguirre CE, García-Villalba R, Beltrán D, et al. Gut blocks activation of pancreatic stellate cells. Biochemical Bacteria Involved in Ellagic Acid Metabolism To Yield Human Pharmacology, 2005(6):70.
Urolithin Metabotypes Revealed. J Agric Food Chem, 2023, [24]Lv Guang. Inhibitory Effect and Mechanism of Ellagic Acid 71(9): 4029-4035. on Lipopolysaccharide-Induced Inflammatory Response. Jilin [17]Ploumi C, Daskalaki I, Tavernarakis N. Mitochondrial University, 2017. biogenesis and clearance: a balancing act. The FEBS Journal, [25]LU Yuting, LI Jun, ZHOU Xianjie, et al. Effect and 2017, 284(2): 183-195. mechanism of ellagic acid on muscle function improvement in [18]D‘Amico D, Pénélope A. Andreux, Pamela Valdés, et al. mice. Medical Journal of the Chinese People‘s Armed Police Impact of the Natural Compound Urolithin A on Health, Disease, Forces, 2020 31(4):324-327.
and Aging. Trends in Molecular Medicine, 2021, 27(7): 687-699. [26]Liu CF, Li X, Zhang ZL, et al. Antiaging effects of Urolithin [19]Tang Pengcheng, Jiao Shirong, Tang Yuanmou, et A on replicative senescent human skin fibroblasts. Rejuvenation
al. Comparison and Study on the Antioxidant Activity of Research, 2019, 22(3): 191-200. Pomegranate Peel Extract. Food Research And Development, [27]JIANG Xiaoquan, YANG Wenning, SEN Muli, et al. 2012, 33(1): 12-15. Material Basis Study on the Protective Effectof Punica Granatum [20]Galano Annia, Francisco Marquez Misaela, Pérez-González L. on Central Nervous SystemBased on Multicomponent Adriana. Ellagic acid: an unusually versatile protector against Sequential Metabolism, Journal ofthinese Mass Spectrometry
oxidative stress. Chemical Research in Toxicology, 2014, 27(5): Seclety, 2022, 43(3): 312-325. 904-918.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 by the authors.
This work is licensed under a Creative Commons Attribution 4.0 International License.
