ApoE Proteins and the Pathogenesis of Alzheimer‘s Disease and Its Early Diagnosis Progress

Abstract

With the quick pace of the society, changing of the majority part of the population age distribution, and the aggravation of the population aging results in the gradual growth of Alzheimer disease (AD) patients’ percentage. Nowadays, researchers are still not totally clear about the etiology and pathogenesis of AD; nonetheless, two hypotheses have emerged: AB amyloid protein and ApoE4 apolipoprotein hypothesis. This paper aims to go through the introduction of ApoE4, then elaborate on the pathogenic mechanism of the ApoE4 hypothesis in AD disease, and finally analyze the new detection method of AD disease. Last but not least, determining whether people suffer from AD and the degree of AD disease through whether tau181 site phosphorylation. This paper provides minimal help for researchers to conduct deeper detection and research in the future. In the future, studying the exact pathogenesis of AD, more perfect AD detection protocols, and ways to treat different levels of AD will still be some of the main challenges that researchers will face when conducting more in-depth research in the field of AD.