Relationship between Vitamin D and Insomnia in Older Adults
DOI:
https://doi.org/10.61173/qm992943Keywords:
Vitamin D, insomnia, older adultsAbstract
Vitamin D is one of the common fat-soluble vitamins, which can be obtained from ultraviolet exposure and intake from particular food or supplementation. Insomnia caused by many reasons like diseases or health status, would also increase possibilities of suffering from other diseases, and has a prevalence to be common among all sorts of people, especially in older adults. Researchers found vitamin D associated with neurotransmitters, oxidative stress and inflammation. Many research also suggest vitamin D are relevant to insomnia, people with low serum vitamin D concentration have a higher possibility to suffer from insomnia, after a period time of supplementation of vitamin D insomnia patients, many of them get improved, but there are no significant difference on some on them either. The mechanism about vitamin D improving insomnia symptoms is not clear, there is no determine recommended dose and duration for patient, and also not enough clinical trials for further exploration. As an auxiliary means of insomnia treatment, vitamin D may have a good performance combined with other therapies. The current review summarizes some mechanism of vitamin D, both positive and negative evidence associated with vitamin D improves insomnia symptom, and have an outlook for the future study on insomnia between vitamin D.
References
[1] Roth, Thomas. “Insomnia: definition, prevalence, etiology, and consequences.” Journal of clinical sleep medicine 3.5 suppl (2007): S7-S10.
[2] Hirshkowitz, Max et al. “National Sleep Foundation’s sleep time duration recommendations: methodology and results summary.” Sleep health vol. 1,1 (2015): 40-43.
[3] Crowley, K. Sleep and Sleep Disorders in Older Adults. Neuropsychol Rev 21, 41–53 (2011).
[4] Bhaskar, Swapna et al. “Prevalence of chronic insomnia in adult patients and its correlation with medical comorbidities.” Journal of family medicine and primary care vol. 5,4 (2016): 780-784.
[5] Riemann, D., Krone, L.B., Wulff, K. et al. Sleep, insomnia, and depression. Neuropsychopharmacol. 45, 74–89 (2020).
[6] LeBlanc, Erin S., et al. “Insomnia is associated with an increased risk of type 2 diabetes in the clinical setting.” BMJ Open Diabetes Research and Care 6.1 (2018): e000604.
[7] Taylor, Daniel J., et al. “Epidemiology of insomnia, depression, and anxiety.” Sleep 28.11 (2005): 1457-1464.
[8] Morin CM, Benca R. Chronic insomnia. Lancet. 2012 Mar 24;379(9821):1129-41. doi: 10.1016/S0140-6736(11)60750- 2. Epub 2012 Jan 20. Erratum in: Lancet. 2012 Apr 21;379(9825):1488. PMID: 22265700.
[9] Benca, Ruth M. “Diagnosis and treatment of chronic insomnia: a review.” Psychiatric services (Washington, D.C.) vol. 56,3 (2005): 332-43.
[10] Schiza, Sophia, et al. “Vitamin D deficiency: a forgotten aspect in Sleep disorders? A critical update.” Sleep Medicine (2024).
[11] Norman, Anthony W. “From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health.” The American journal of clinical nutrition vol. 88,2 (2008): 491S-499S.
[12] Muzur, Amir, Edward F. Pace-Schott, and J. Allan Hobson. “The prefrontal cortex in sleep.” Trends in cognitive sciences 6.11 (2002): 475-481.
[13] Archontogeorgis, Kostas, Evangelia Nena, and Paschalis Steiropoulos. “Linking Vitamin D and Sleep.” Neurological Modulation of Sleep. Academic Press, 2020. 385-399.
[14] Zhang, Cun, et al. “Vitamin D inhibits TNF-α induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathway.” Journal of Orthopaedic Surgery and Research 16 (2021): 1-8.
[15] Koivisto, Oona, Andrea Hanel, and Carsten Carlberg. “Key vitamin D target genes with functions in the immune system.” Nutrients 12.4 (2020): 1140.
[16] Yong-ci, H. A. O., et al. “The correlation of vitamin D level with sleep quality and mood in patients with chronic insomnia.” Chinese Journal of Contemporary Neurology & Neurosurgery 23.8 (2023).
[17] Zhao, Kai, et al. “Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2 months.” Clinica Chimica Acta 475 (2017): 147-151.
[18] JOSEPH, MARIA JAI, and KARTHIK VP. “EVALUATION OF VITAMIN D SERUM LEVELS IN PATIENTS WITH INSOMNIA.” EVALUATION 11.11 (2018).
[19] WU, Zixing, et al. “Correlations of Cognitive Function with Insomnia Severity, Serum Levels of 25-hydroxy Vitamin D3 and Tumor Necrosis Factor-α in Elderly Patients with Chronic Insomnia.” Chinese General Practice 27.03 (2024): 328.
[20] Okudur, Saadet Koc, and Pinar Soysal. “Excessive daytime sleepiness is associated with malnutrition, dysphagia, and vitamin D deficiency in older adults.” Journal of the American Medical Directors Association 22.10 (2021): 2134-2139.
[21] Shahi, M. Mohammad, et al. “The effect of vitamin D supplement on quality of sleep in adult people with sleep disorders.” (2017): 443-448.
[22] Zhu F. Clinical study of Shensong Yangxin Capsule combined with vitamin D in the treatment of essential hypertension [J]. New Chinese Medicine,2018,50(01):23-25.
[23] Huang, Wei, et al. “Improvement of pain, sleep, and quality of life in chronic pain patients with vitamin D supplementation.” The Clinical journal of pain 29.4 (2013): 341-347.
[24] Kaviani, Mina, et al. “Effects of vitamin D supplementation on depression and some involved
[25] Sikoglu, Elif M., et al. “Vitamin D3 supplemental treatment for mania in youth with bipolar spectrum disorders.” Journal of child and adolescent psychopharmacology 25.5 (2015): 415-424.
[26] Siegel, Jerome M. “The neurotransmitters of sleep.” The Journal of clinical psychiatry vol. 65 Suppl 16,Suppl 16 (2004): 4-7.
[27] Larsen, A U et al. “No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial.” Sleep medicine: X vol. 3 100040. 19 Oct. 2021,
[28] Riemann, Dieter, et al. “The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023.” Journal of sleep research 32.6 (2023): e14035.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 by the authors.
This work is licensed under a Creative Commons Attribution 4.0 International License.
