Epidemiology, Pathogenesis, and Vaccine Development of Acne

Abstract

Acne is a widespread and chronic inflammatory disease of the pilosebaceous glands affecting millions of people worldwide, particularly among adolescents. The current treatment method is mainly oral and smear medication, combined with a variety of physical and chemical therapy used as adjuvant therapy, alternative therapy or sequelae treatment. However, due to antibiotic resistance and bacteria evolve over time, need a vaccine as a new alternative treatment, in recent years, with the rapid development of molecular biology and immunology, based on specific antigen antibody technology acne vaccine has made significant progress, but there is still no successful development of acne vaccine. This paper analyzes the main four pathogenesis of acne and the current treatment, including oral and daub anti-inflammatory drugs and antibacterial drugs, supplemented by physical and chemical therapy, focus on the development of acne vaccine, present situation, challenges and future trend, hope to further promote the research and development of acne vaccine provide certain theoretical basis and reference value, and provide new ideas and methods for the prevention and treatment of acne. And acne pathogenesis complex and cannot determine the vaccine clinical trial effect these two problems are not solved, pathogenic mechanism involves multiple complex factors, a single vaccine may not have enough protective effect, difficult to completely prevent or cure acne, therefore, the next step need to consider targeting multiple pathogens and virulence factors combination of multivalent vaccine, and need for long-term clinical trials and observation.