Anti-inflammatory response controlled by gamma wave
DOI:
https://doi.org/10.61173/w23pyc23Keywords:
gamma wave, microglia, Alzheimer's disease, Anti-inflammatory ResponseAbstract
It is now believed that the cause of Alzheimer’s disease is the accumulation of amyloid-Bata, which is caused by a variety of factors, such as neuroinflammation. So in this study, the researchers will study the changes of microglia from M1 to M2 by changing the frequency of gamma wave. If microglia change from M1 to M2, that means it changes from pro-inflammatory to anti-inflammatory.
References
[1] De-Paula, V.J., Radanovic, M., Diniz, B., Forlenza, O. (2012). Alzheimer’s Disease. In: Harris, J. (eds) Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease. Subcellular Biochemistry, vol 65. Springer, Dordrecht. https:// doi.org/10.1007/978-94-007-5416-4_14
[2] Iaccarino, H. F., Singer, A. C., Martorell, A. J., Rudenko, A., Gao, F., Gillingham, T. Z., Mathys, H., Seo, J., Kritskiy, O., Abdurrob, F., Adaikkan, C., Canter, R. G., Rueda, R., Brown, E. N., Boyden, E. S., & Tsai, L. H. (2016). Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature, 540(7632), 230–235. https://doi.org/10.1038/ nature20587
[3] Huang, Y., Happonen, K. E., Burrola, P. G., O’Connor, C., Hah, N., Huang, L., Nimmerjahn, A., & Lemke, G. (2021). Microglia use TAM receptors to detect and engulf amyloid β plaques. Nature immunology, 22(5), 586–594. https://doi. org/10.1038/s41590-021-00913-5
[4] Elyamany, O., Leicht, G., Herrmann, C.S. et al. Transcranial alternating current stimulation (tACS): from basic mechanisms towards first applications in psychiatry. Eur Arch Psychiatry Clin Neurosci 271, 135–156 (2021). https://doi.org/10.1007/ s00406-020-01209-9
[5] Helfrich, R. F., Schneider, T. R., Rach, S., Trautmann- Lengsfeld, S. A., Engel, A. K., & Herrmann, C. S. (2014). Entrainment of brain oscillations by transcranial alternating current stimulation. Current biology : CB, 24(3), 333–339. https://doi.org/10.1016/j.cub.2013.12.041
[6] Hiramoto, M., & Cline, H. T. (2021). Precisely controlled visual stimulation to study experience-dependent neural plasticity in Xenopus tadpoles. STAR protocols, 2(1), 100252. https://doi.org/10.1016/j.xpro.2020.100252
[7] Im, K., Mareninov, S., Diaz, M. F. P., & Yong, W. H. (2019). An Introduction to Performing Immunofluorescence Staining. Methods in molecular biology (Clifton, N.J.), 1897, 299–311. https://doi.org/10.1007/978-1-4939-8935-5_26
[8] Useing FCM flow cytometry. First is sample Preparation. Isolation of Macrophages: Isolate macrophages from the sample using appropriate techniques (e.g., from tissue, cell culture, or peripheral blood mononuclear cells).
[9] Martin, E., El-Behi, M., Fontaine, B., & Delarasse, C. (2017). Analysis of Microglia and Monocyte-derived Macrophages from the Central Nervous System by Flow Cytometry. Journal of visualized experiments : JoVE, (124), 55781. https://doi. org/10.3791/55781
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