Reducing Synaptic Plasticity Decreases Resilience to Depression and Anxiety in an ASCL1 Mouse Model
DOI:
https://doi.org/10.61173/wbft0v77Keywords:
synaptic plasticity, depression, anxiety, stress, neuroplasticityAbstract
Synaptic plasticity, the ability of synapses to strengthen or weaken over time in response to activity, plays a crucial role in the brain’s adaptability and function. This paper examines the impact of synaptic plasticity on resilience to depression and anxiety in an ASCL1 mouse model. By studying the molecular and cellular mechanisms of synaptic changes, how these changes affect behavioral outcomes related to stress and emotional regulation analysis. Through the research and findings of this paper, a deeper understanding of the relationship between the enhancement of synaptic plasticity and mood changes, and provide more treatment ideas for depression and emotion-related diseases.
References
[1] Price, R. B., & Duman, R. (2020). Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model. Molecular psychiatry, 25(3), 530–543. https://doi.org/10.1038/s41380-019-0615-x
[2] Pittenger,C., & Duman, R. S. (2008). Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology, 33(1), 88–109. https:// doi.org/10.1038/sj.npp.1301574
[3] Planchez, B., Lagunas, N., Le Guisquet, A. M., Legrand, M., Surget, A., Hen, R., & Belzung, C. (2021). Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression. Cells, 10(5), 972. https://doi.org/10.3390/ cells10050972
[4] Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016). Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature medicine, 22(3), 238–249. https://doi.org/10.1038/nm.4050
[5] Qureshi, T., Ali, S., & Fahad, T. (2024). Synergistic Effect of Coenzyme Q10 and L-Carnitine on Gliosis and Anhedonia, in a Rat Model of Multiple Sclerosis: An Immunohistochemical Study. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 22(3), 484–492. https://doi. org/10.9758/cpn.23.1150
[6] Kawasaki, Y., Saito, M., Won, J., Bae, J. Y., Sato, H., Toyoda, H., Kuramoto, E., Kogo, M., Tanaka, T., Kaneko, T., Oh, S. B., Bae, Y. C., & Kang, Y. (2018). Inhibition of GluR Current in Microvilli of Sensory Neurons via Na+-Microdomain Coupling Among GluR, HCN Channel, and Na+/K+ Pump. Frontiers in cellular neuroscience, 12, 113. https://doi.org/10.3389/ fncel.2018.00113
[7] Toni, N., Teng, E. M., Bushong, E. A., Aimone, J. B., Zhao, C., Consiglio, A., van Praag, H., Martone, M. E., Ellisman, M. H., & Gage, F. H. (2007). Synapse formation on neurons born in the adult hippocampus. Nature neuroscience, 10(6), 727–734. https://doi.org/10.1038/nn1908
[8] Moore, C. L., Savenka, A. V., & Basnakian, A. G. (2021). TUNEL Assay: A Powerful Tool for Kidney Injury Evaluation. International journal of molecular sciences, 22(1), 412. https:// doi.org/10.3390/ijms22010412Tagawa, N., Mori, K., Koebis, M., Aiba, A., Iino, Y., Tsuneoka, Y., & Funato, H. (2024). Activation of lateral preoptic neurons is associated with nestbuilding in male mice. Scientific reports, 14(1), 8346. https://doi. org/10.1038/s41598-024-59061-z
[9] Dionisie, V., Ciobanu, A. M., Toma, V. A., Manea, M. C., Baldea, I., Olteanu, D., Sevastre-Berghian, A., Clichici, S., Manea, M., Riga, S., & Filip, G. A. (2021). Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress. International journal of molecular sciences, 22(14), 7483. https://doi. org/10.3390/ijms22147483
[10] Ma, C., Zhang, Y. B., Ho, S. H., Xing, D. F., Ren, N. Q., & Liu, B. F. (2017). Cell growth and lipid accumulation of a microalgal mutant Scenedesmus sp. Z-4 by combining light/dark cycle with temperature variation. Biotechnology for biofuels, 10, 260. https://doi.org/10.1186/s13068-017-0948-0
[11] Matsuo, T., Uchida, T., Yamashita, K., Takei, S., Ido, D., Fujiwara, A., Iino, M., & Oguchi, M. (2019). Vision evaluation by functional observational battery, operant behavior test, and light/dark box test in retinal dystrophic RCS rats versus normal rats. Heliyon, 5(6), e01936. https://doi.org/10.1016/ j.heliyon.2019.e01936
[12] Garcia-Garcia, A. L., Navarro-Sobrino, M., Pilosof, G., Banerjee, P., Dranovsky, A., & Leonardo, E. D. (2016). 5-HT 1A Agonist Properties Contribute to a Robust Response to Vilazodone in the Novelty Suppressed Feeding Paradigm. The international journal of neuropsychopharmacology, 19(10), pyw057. https://doi.org/10.1093/ijnp/pyw057
[13] Chaung, K., Baharav, T. Z., Henderson, G., Zheludev, I. N., Wang, P. L., & Salzman, J. (2023). SPLASH: a statistical, reference-free genomic algorithm unifies biological discovery. bioRxiv : the preprint server for biology, 2022.06.24.497555. https://doi.org/10.1101/2022.06.24.497555
[14] Ning, H., Cao, D., Wang, H., Kang, B., Xie, S., & Meng, Y. (2017). Effects of haloperidol, olanzapine, ziprasidone, and PHA-543613 on spatial learning and memory in the Morris water maze test in naïve and MK-801-treated mice. Brain and behavior, 7(8), e00764. https://doi.org/10.1002/brb3.764 Dean&Francis
[15] Rygvold, T. W., Hatlestad-Hall, C., Elvsåshagen, T., Moberget, T., & Andersson, S. (2022). Long-Term Potentiation- Like Visual Synaptic Plasticity Is Negatively Associated With Self-Reported Symptoms of Depression and Stress in Healthy Adults. Frontiers in human neuroscience, 16, 867675. https:// doi.org/10.3389/fnhum.2022.867675
Downloads
Published
Issue
Section
License
Copyright (c) 2024 by the authors.
This work is licensed under a Creative Commons Attribution 4.0 International License.
