Impact of Adult Hippocampal Neurogenesis on Neuronal Output Patterns from the Subiculum to the Lateral Hippocampus During Anxiety
DOI:
https://doi.org/10.61173/e7vydr87Keywords:
Adult Hippocampal Neurogenesis, Depression, Hippocampus, SubiculumAbstract
Adult hippocampal neurogenesis (AHN) has an effect on mood regulations. Promoting AHN could recover stressed-induced symptoms such as depression and anxiety. In this study, we used voluntary physical exercise, fosTRAP2, functional magnetic resonance imaging (FMRI) and positron emission tomography (PET) technology to evaluate the effect of AHN on mice during unpredictable chronic mild stress (UCMS). Additionally, we inject fluoxetine to increase AHN.
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[4] Deborah R. Glasofer, PhD Anxiety vs. Depression Symptoms Figure 2: Neurons marked by fosTRAP2 and Treatment.2022 https://www.verywellmind.com/am-itechnology. Red:fosTRAP, blue:DAPI [14] anxious-4045683 3. Results from previous studies [5] Planchez, B.; Lagunas, N.;Le Guisquet, A.-M.; Legrand, M.;Surget, A.; Hen, R.; Belzung, C.Increasing The experiments proved that increasing AHN in mice Adult Hippocampal Neurogenesis Promotes Resilience in a alters the output pattern of specific neurons populations Mouse Model of Depression. Cells 2021, 10, 972. https://doi. in the subiculum to the lateral hippocampus under anx- org/10.3390/cells10050972 iety conditions. The fluorescence neurons and activity [6] Marco Carli1,#, Stefano Aringhieri1,#, Shivakumar in hypothalamus and subiculum should be observed in Kolachalam1, Biancamaria Longoni1, Giovanna Grenno1 Mario groups with neurogenesis compared to the control groups Rossi2 Angelo Gemignani3, Francesco Fornai1,4, Roberto with CORT injection. Furthermore, control groups with- Maggio5 and Marco Scarselli1,*Current Neuropharmacology, out CORT injection could also be observed to have less 2021, 19, 1640-1660DOI: 10.2174/1570159X186662008181949 TRAPed neurons in the subiculum and lateral hypothal- 48 amus in order to verify the validity of the methods. Fur- [7] Neurobiology of anesthetic-surgical stress and induced thermore, the results indicate that it is possible to alleviate behavioral changes in dogs and cats: A review I. Hernándezdepression by increasing AHN in which could reduce the Avalos,1 E. Flores-Gasca,2 D. Mota-Rojas,3 A. Casaspopulation of the neurons in the subiculum and lateral Alvarado,4 A. E. Miranda-Cortés,1 and A. Domínguez-Oliva1 hippocampus and this method could be used in human. [8] Acute or Chronic Exposure to Corticosterone Promotes 4. Discussion Wakefulness in Mice Zhen Yao, Bei-Xuan Zhang, Hui Chen, Xiao-Wei Jiang, Wei-Min Qu,Zhi-Li Huang In the experimental methods, fosTRAP2, FMRI and PET [9] Patterns of Neural Activation During an Initial Social Stress technology were used to prove whether increasing AHN Encounter are Predictive of Future Susceptibility or Resilience: in mice alters the output pattern of specific neurons popu- A FosTRAP2 Study Dalia Murra1,2, Kathryn L. Hilde1 ,Huzefa lations in the subiculum to the lateral hippocampus under Khalil1, Stanley J. Watson Jr.1,2,3, Huda Akil1,2,3 anxiety conditions, which is also the hypothesis of this [10] Timothy J. Schoenfeld and Chance Swanson.Potential Role experiment. for Endorphins in Exercise Effects on Adult Neurogenesis,2021. In the future, we could make deeper research on the effect [11] James P. Herman’, William E. Cullinan2, Maria lnes of AHN on anxiety and depression in hypothalamus and Morano2, Huda Aki12 and Stanley J. Watson2Contribution of the subiculum in order to take this experiment further and we Ventral Subiculum to Inhibitory Regulation of the Hypot halamo- Dean&Francis Pituitary-Adrenocortical Axis,Journal of Neuroeridocrinolo~y, & COGNITIVE-BEHAVIORAL THERAPY IN TREATMENT- 1995, Vol. 7, 47s-482 RESISTANT DEPRESSION TREATMENT. 2021
[12] A guideline proposal for mice preparation and care in [14] Patterns of Neural Activation During an Initial Social 18F-FDG PET imaging F. M. Ribeiro,1 P. M. M. Correia,1 A. C. Stress Encounter are Predictive of Future Susceptibility or Santos,2 and J. F. C. A. Veloso1 Resilience: A FosTRAP2 Study Dalia Murra1,2, Kathryn L.
[13] ALPTEKIN AYDIN. MOST EFFECTIVE TREATMENT Hilde1 ,Huzefa Khalil1, Stanley J. Watson Jr.1,2,3, Huda COMBINING TRANSCRANIAL MAGNETIC STIMULATION Akil1,2,3
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