The Impact of Local Ketamine on Spatial Cognition Through Dopamine
DOI:
https://doi.org/10.61173/1yfwv521Keywords:
Ketamine, Hippocampus, Dopamine, VTA, Spatial CognitionAbstract
The dopamine system plays a crucial role in maintaining spatial cognitive functions. Ketamine, a non-competitive NMDA receptor antagonist, indirectly affects dopamine release and function by modulating glutamatergic neuronal activity, leading to spatial cognitive impairments. This study aims to explore the specific mechanisms through which local ketamine administration affects spatial cognition. By injecting ketamine into the hippocampus of mice and combining behavioral experiments with brain tissue analysis, we found that ketamine-induced dopamine damage significantly impairs the mice’s spatial orientation abilities. This discovery offers new insights into the negative impact of ketamine addiction on cognitive function.
References
[1] Kokkinou, M., Ashok, A. & Howes, O. The effects of ketamine on dopaminergic function: meta-analysis and review of Dean&Francis the implications for neuropsychiatric disorders. Mol Psychiatry 23, 59–69 (2018). https://doi.org/10.1038/mp.2017.190
[2] Ketamine fast facts. (n.d.). National Drug Intelligence Center a component of the U.S. Department of Justice.
[3] Nieoullon A. Dopamine and the regulation of cognition and attention. Prog Neurobiol. 2002;67(1):53-83. doi:10.1016/s0301- 0082(02)00011-4
[4] Thurm F, Schuck NW, Fauser M, et al. Dopamine modulation of spatial navigation memory in Parkinson’s disease. Neurobiol Aging. 2016;38:93-103. doi:10.1016/ j.neurobiolaging.2015.10.019
[5] Kempadoo KA, Mosharov EV, Choi SJ, Sulzer D, Kandel ER. Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory. Proc Natl Acad Sci U S A. 2016;113(51):14835-14840. doi:10.1073/ pnas.1616515114
[5] Burgess N. (2008). Spatial cognition and the brain. Annals of the New York Academy of Sciences, 1124, 77–97. https://doi. org/10.1196/annals.1440.002
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