Exploring the Mechanisms and Functions of the Impact of Ketamine on Spatial Orientation Decision Making
DOI:
https://doi.org/10.61173/h9s7ym30Keywords:
ketamine, sound perception, spatial orientation, TeA(temporal association area)Abstract
The aim of the study is to explore the impact of ketamine on sound perception and spatial orientation decision making, and the mechanism of how ketamine impacts perception and decision abilities. The methods used include behavioral and histology approaches. From the results, it can be concluded one of the brain regions affected by ketamine is TeA(temporal association area), which plays a vital role in sound perception and spatial orientation. An unexpected finding is that ketamine impacts left turning and right turning decisions at different degree, which requires further research on ketamine’s different impact on two cerebral hemispheres. In all, the study’s findings help people further understand how ketamine impacts spatial and sound perception.
References
[1] Slobodan Mihaljević, Matko Pavlović, Krešimir Reiner, Marko Ćaćić(2020). Therapeutic Mechanisms of Ketamine. Psychiatr Danub.2020 Autumn-Winter;32(3-4):325-333.
[2] Rebecca L, Dean Claudia(2021). Ketamine and other glutamate receptor modulators for depression in adults with Fig.5 the average signal of left turn and right unipolar major depressive disorder. Cochrane Database Syst turn Rev.2021 Sep 12;9(9):CD011612.
[3] Marko A Peltoniemi 1, Nora M Hagelberg(2016). Ketamine: 4. Conclusion A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Clin Pharmacokinet. 2016 From the difference in left-turning and right-turning sig- Sep;55(9):1059-77. nals in mice’s TeA brain region and a peak-shaped acti- [4]Jansen K (2001). Ketamine: Dreams and Realities. Dean&Francis Multidisciplinary Association for Psychedelic Studies. p.122. sensorineural hearing impairment. Front Neurosci. 2023 Jan
[5] Mathew SJ, Zarate Jr CA (2016). Ketamine for Treatment- 17:16:1080398. Resistant Depression: The First Decade of Progress. Springer. [10]L Feigin 1, G Tasaka 1, I Maor 1, A Mizrahi(2021). Sparse pp. 8–10, 14–22. Coding in Temporal Association Cortex Improves Complex
[6] Edvard I Moser 1, Emilio Kropff (2008). Place cells, grid Sound Discriminability. J Neurosci. 2021 Aug 18;41(33):7048- cells, and the brain’s spatial representation system. Annu Rev 7064. Neurosci. 2008:31:69-89. [11]Evan M Hess 1, Lace M Riggs(2022). Mechanisms of
[7] May-Britt Moser, David C Rowland, Edvard I Moser (2015). ketamine and its metabolites as antidepressants. Biochem Place cells, grid cells, and memory. Cold Spring Harb Perspect Pharmacol. 2022 Mar:197:114892. Biol. 2015 Feb 2;7(2):a021808. [12]Brooke Short 1, Joanna Fong(2018). Side-effects associated
[8] Edvard I Moser 1, Emilio Kropff (2008). Place cells, grid with ketamine use in depression: a systematic review. Lancet cells, and the brain’s spatial representation system. Annu Rev Psychiatry. 2018 Jan;5(1):65-78. Neurosci. 2008:31:69-89. [13]Slobodan Mihaljević, Matko Pavlović, Krešimir Reiner,
[9] Kavassery Venkateswaran Nisha, Ajith Kumar Uppunda, Marko Ćaćić(2020). Therapeutic Mechanisms of Ketamine. Rakesh Trinesh Kumar(2023). Spatial rehabilitation using Psychiatr Danub.2020 Autumn-Winter;32(3-4):325-333. virtual auditory space training paradigm in individuals with
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