The Effect of Lead (Pb) on Mice’s Parathyroid Gland’s Regulation of Calcium Level

Authors

  • Ruotong Zhang

DOI:

https://doi.org/10.61173/594yat07

Keywords:

Lead (Pb) Exposure, Parathyroid Hormone (PTH), Calcium-Sensing Receptor (CaSR), Vitamin D, Glutathione (GSH) Activity, Oxidative Stress, Flint Water Crisis, Calcium Homeostasis

Abstract

This study will use biochemical markers that include parathyroid hormone (PTH) levels, calcium-sensing receptor (CaSR) expression, Vitamin D levels, and glutathione (GSH) activity to study the effects of lead (Pb) exposure on mice. We can understand how Pb affects calcium regulation, oxidative stress response, and calcium homeostasis using these biomarkers. The experiment is conducted using ELISA, flow cytometry (FACS), and GSH assays with mice exposed to Pb. Our results suggest that lead exposure can lead to several outcomes: biomarkers are affected significantly, biomarkers are partially affected with some unchanged, and biomarkers are completely unaffected. These results are relevant to real world environmental health crises like the Flint water crisis because Pb contamination led to health problems. The goal of understanding the mechanisms of Pb toxicity is to help inform people to mitigate the negative effects of Pb exposure.

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Published

2024-12-31

Issue

Vol. 2 No. 6 (2024): Volume 2, Issue 6

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